Results 51 to 60 of about 219,333 (243)

Mechanism for CCC DNA synthesis in hepadnaviruses. [PDF]

PLoS ONE, 2009
Hepadnavirus replication requires the synthesis of a covalently closed circular (CCC) DNA from the relaxed circular (RC) viral genome by an unknown mechanism.
Ji A Sohn, Samuel Litwin, Christoph Seeger   +2 more
doaj   +1 more source

DNA–protein crosslink repair: proteases as DNA repair enzymes

Trends in Biochemical Sciences, 2015
DNA-protein crosslinks (DPCs) are highly toxic DNA lesions because they interfere with DNA transactions. The recent discovery of a yeast protease that processes DPCs proteolytically raises the question whether DPC proteases also exist in higher eukaryotes.
Julian Stingele, Bianca Habermann, Stefan Jentsch   +2 more
openaire   +4 more sources

Pharmacogenetics of Cancer and DNA Repair Enzymes [PDF]

, 2011
Pharmacogenetics is focused on finding associations between drug response and the genetic background of a patient.38 Resequencing of the human genome revealed that nucleotide variation between individuals exists in 0.1% of the genome, which corresponds to 3 million differences.
Tahar van der Straaten, Leon Mullenders, Henk-Jan Guchelaar   +2 more
openaire   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The role of HECT-type E3 ubiquitin ligases in DNA damage response and repair

Cell Death Discovery
The post-translational modification ubiquitination consists in a three-step reaction triggered by E1 ubiquitin activating enzymes, E2 ubiquitin conjugating enzymes, and E3 ubiquitin ligases.
Sara Giovannini, Claudia Fiorilli, Valeria Moriconi, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola   +6 more
doaj   +1 more source

Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting

Frontiers in Oncology, 2019
Radiation therapy (RT) is widely used in cancer care strategies. Its effectiveness relies mainly on its ability to cause lethal damage to the DNA of cancer cells.
Julian Biau, Julian Biau, Julian Biau, Julian Biau, Julian Biau, Julian Biau, Emmanuel Chautard, Emmanuel Chautard, Pierre Verrelle, Pierre Verrelle, Pierre Verrelle, Pierre Verrelle, Marie Dutreix, Marie Dutreix, Marie Dutreix, Marie Dutreix   +15 more
doaj   +1 more source

Predictors of hepatitis B cure using gene therapy to deliver DNA cleavage enzymes: a mathematical modeling approach. [PDF]

PLoS Computational Biology, 2013
Most chronic viral infections are managed with small molecule therapies that inhibit replication but are not curative because non-replicating viral forms can persist despite decades of suppressive treatment.
Joshua T Schiffer, Dave A Swan, Daniel Stone, Keith R Jerome   +3 more
doaj   +1 more source

DNA Polymerase λ, a Novel DNA Repair Enzyme in Human Cells [PDF]

Journal of Biological Chemistry, 2002
DNA polymerase lambda (pol lambda) is a novel family X DNA polymerase that has been suggested to play a role in meiotic recombination and DNA repair. The recent demonstration of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in pol lambda supports a function of this enzyme in base excision repair.
García Díaz, Miguel, Bebenek, Katarzyna, Sabariegos, Rosario, Domínguez, Orlando, Rodríguez, Josana Renato, Kirchhoff, Tomas, García Palomero, Esther, Picher, Ángel J., Juárez, Raquel, Ruiz Pérez, José Francisco, Kunkel, Thomas A., Blanco, Luis   +11 more
openaire   +5 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source