Results 51 to 60 of about 225,059 (304)

The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress

Nature Communications
RIF1 is a multifunctional protein that regulates DNA replication and repair. RIF1-deficient cells are hypersensitive to DNA replication stress. Of the two alternatively spliced RIF1 isoforms, called RIF1-Short and RIF1-Long, the RIF1-Long isoform is more
Qianqian Dong, Matthew Day, Yuichiro Saito, Emma Parker, Lotte P. Watts, Masato T. Kanemaki, Antony W. Oliver, Laurence H. Pearl, Shin-ichiro Hiraga, Anne D. Donaldson   +9 more
doaj   +1 more source

Enzyme Structures: DNA repair flips out [PDF]

Current Biology, 1995
New insights into the workings of the repair enzymes that police the genome for damage to DNA come from the recently determined structures of two uracil-DNA glycosylases.
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Overexpression of enzymes that repair endogenous damage to DNA [PDF]

European Journal of Biochemistry, 2000
A significant contribution to human mutagenesis and carcinogenesis may come from DNA damage of endogenous, rather than exogenous, origin. Efficient repair mechanisms have evolved to cope with this. The main repair pathway involved in repair of endogenous damage is DNA base excision repair.
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

PCNA and XPF cooperate to distort DNA substrates [PDF]

, 2009
XPF is a structure-specific endonuclease that preferentially cleaves 3' DNA flaps during a variety of repair processes. The crystal structure of a crenarchaeal XPF protein bound to a DNA duplex yielded insights into how XPF might recognise branched DNA ...
J. Carlos Penedo, White, Malcolm F, Timothy D. Craggs, Penedo, J.C., Craggs, T.D., Penedo, Carlos, Richard D. Hutton, Hutton, R.D., Malcolm F. White, Richard D. Hutton, Hutton, Richard David, Craggs, Timothy David, White, M.F.   +12 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme—The spore photoproduct lyase

, 2017
DNA repair enzymes typically recognize their substrate lesions with high affinity to ensure efficient lesion repair. In UV irradiated endospores, a special thymine dimer, 5-thyminyl-5,6-dihydrothymine, termed the spore photoproduct (SP), is the dominant ...
Jian, Yajun, Lei Li, Yajun Jian, Linlin Yang, Peter Setlow, Setlow, Peter, Yang, Linlin, Li, Lei   +7 more
core   +1 more source