Results 71 to 80 of about 225,059 (304)

DNA Polymerase λ, a Novel DNA Repair Enzyme in Human Cells [PDF]

Journal of Biological Chemistry, 2002
DNA polymerase lambda (pol lambda) is a novel family X DNA polymerase that has been suggested to play a role in meiotic recombination and DNA repair. The recent demonstration of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in pol lambda supports a function of this enzyme in base excision repair.
García Díaz, Miguel, Bebenek, Katarzyna, Sabariegos, Rosario, Domínguez, Orlando, Rodríguez, Josana Renato, Kirchhoff, Tomas, García Palomero, Esther, Picher, Ángel J., Juárez, Raquel, Ruiz Pérez, José Francisco, Kunkel, Thomas A., Blanco, Luis   +11 more
openaire   +5 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Deciphering the interstrand crosslink DNA repair network expressed by Trypanosoma brucei [PDF]

, 2019
Interstrand crosslinks (ICLs) represent a highly toxic form of DNA damage that can block essential biological processes including DNA replication and transcription.
Dittani, A, WILKINSON, S
core  

Role of Base and nucleotide excision repair pathways in processing of clustered DNA lesions induced by ionising radiation

, 2003
Ionising radiation (IR) induces a wide spectrum of lesions in DNA, including double- and single-strand breaks, abasic (AP) sites and a variety of base lesions.
Budworth, Helen Louise, Budworth, Helen Louise.   +1 more
core   +1 more source

Snf2 family ATPases and DExx box helicases:differences and unifying concepts from high-resolution crystal structures [PDF]

, 2006
Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA-protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases,
Owen-Hughes, Tom; id_orcid, Flaus, Andrew, Hopfner, Karl-Peter, Dürr, Harald   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The role of HECT-type E3 ubiquitin ligases in DNA damage response and repair

Cell Death Discovery
The post-translational modification ubiquitination consists in a three-step reaction triggered by E1 ubiquitin activating enzymes, E2 ubiquitin conjugating enzymes, and E3 ubiquitin ligases.
Sara Giovannini, Claudia Fiorilli, Valeria Moriconi, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola   +6 more
doaj   +1 more source

Early Steps in the DNA Base Excision Repair Pathway of a Fission Yeast Schizosaccharomyces pombe

Journal of Nucleic Acids, 2010
DNA base excision repair (BER) accounts for maintaining genomic integrity by removing damaged bases that are generated endogenously or induced by genotoxic agents.
Kyoichiro Kanamitsu, Shogo Ikeda
doaj   +1 more source

Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting

Frontiers in Oncology, 2019
Radiation therapy (RT) is widely used in cancer care strategies. Its effectiveness relies mainly on its ability to cause lethal damage to the DNA of cancer cells.
Julian Biau, Julian Biau, Julian Biau, Julian Biau, Julian Biau, Julian Biau, Emmanuel Chautard, Emmanuel Chautard, Pierre Verrelle, Pierre Verrelle, Pierre Verrelle, Pierre Verrelle, Marie Dutreix, Marie Dutreix, Marie Dutreix, Marie Dutreix   +15 more
doaj   +1 more source