Results 71 to 80 of about 376,771 (302)
TopBP1 utilises a bipartite GINS binding mode to support genome replication
Nature CommunicationsActivation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance.
Matthew Day +13 more
doaj +1 more source
DNA double strand break repair enzymes function at multiple steps in retroviral infection [PDF]
, 2009 (c) 2009 Sakurai et al; licensee BioMed Central Ltd. / This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Sakurai Yasuteru +3 more
core +4 more sources
A Nick-sensing DNA 3′-Repair Enzyme fromArabidopsis [PDF]
Journal of Biological Chemistry, 2002 DNA single-strand breaks, a major cause of genome instability, often produce unconventional end groups that must be processed to restore terminal moieties suitable for reparative DNA gap filling or ligation. Here, we describe a bifunctional repair enzyme from Arabidopsis (named AtZDP) that recognizes DNA strand breaks and catalyzes the removal of 3 ...
PETRUCCO, Stefania +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The basic chemistry of exercise-induced DNA oxidation:oxidative damage, redox signalling and their interplay [PDF]
, 2015 Acute exercise increases reactive oxygen and nitrogen species generation. This phenomenon is associated with two major outcomes: (1) redox signalling and (2) macromolecule damage.
Close, Graeme L. +5 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Scientific Reports, 2017 Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence of
Veslemøy Rolseth +14 more
doaj +1 more source
SIRT1 Enhances the Survival of Human Embryonic Stem Cells by Promoting DNA Repair
Stem Cell Reports, 2017 Summary: Human embryonic stem cells (hESCs) hold great promise for the treatment of many incurable diseases. Sirtuin1 (SIRT1), a class III histone deacetylase, is abundantly expressed in hESCs and is known to regulate early differentiation and telomere ...
Jiho Jang +6 more
doaj +1 more source
Mechanism for CCC DNA synthesis in hepadnaviruses. [PDF]
PLoS ONE, 2009 Hepadnavirus replication requires the synthesis of a covalently closed circular (CCC) DNA from the relaxed circular (RC) viral genome by an unknown mechanism.
Ji A Sohn +2 more
doaj +1 more source
Preventing hereditary cancers caused by opportunistic carcinogens [PDF]
, 2011 Objectives Previous studies reported inherited BRCA1/2 deficits appear to cause cancer by impairing normal protective responses to some carcinogens.
Bernard Friedenson
core +2 more sources