Results 91 to 100 of about 2,604,485 (241)

Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients. [PDF]

, 2010
Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined groups of patients with colorectal cancer (CRC, n = 89), benign adenoma (AD, n = 77) and ...
Swoboda, Maja, Guz, Jolanta, Speina, Elzbieta, Oliński, Ryszard, Janowska, Beata, Obtułowicz, Tomasz, Janik, Justyna, Dziaman, Tomasz, Szpila, Anna, Siomek, Agnieszka, Cieśla, Jarosław M., Jawien, Arkadiusz, Gackowski, Daniel, Rozalski, Rafał, Tudek, Barbara, Banaszkiewicz, Zbigniew   +15 more
core   +2 more sources

CONTRIBUTION OF DNA REPAIR ENZYMES GENES POLYMORPHISM TO CHROMOSOMAL MUTAGENESIS IN HUMAN LYMPHOCYTES (REVIEW)

Вестник Кемеровского государственного университета, 2013
A review of scientific publications on the analysis of the correlation between chromosome aberrations and DNA repair enzymes genes polymorphism in healthy individuals and cancer patients is provided.
V. I. Minina
doaj  

Protein–Protein Interactions in Base Excision Repair

Biomolecules
The Base Excision Repair (BER) pathway involves a highly coordinated series of protein–protein interactions that facilitate the recognition, excision, and repair of damaged bases. Key enzymes such as DNA glycosylases, apurinic/apyrimidinic endonuclease 1
Govardhan Rathnaiah, Joann B. Sweasy
doaj   +1 more source

Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme—The spore photoproduct lyase

, 2017
DNA repair enzymes typically recognize their substrate lesions with high affinity to ensure efficient lesion repair. In UV irradiated endospores, a special thymine dimer, 5-thyminyl-5,6-dihydrothymine, termed the spore photoproduct (SP), is the dominant ...
Jian, Yajun, Lei Li, Yajun Jian, Linlin Yang, Peter Setlow, Setlow, Peter, Yang, Linlin, Li, Lei   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Interactome analysis and docking site prediction of DNA X-ray repair cross-complementing protein (XRCC) in Arabidopsis thaliana [PDF]

Network Biology, 2020
There are seven homologs in eukaryotic RAD51 gene family which are conserved among animals and plants, and those are RAD51, DMC1, RAD51c, XRCC3, RAD51b, RAD51d and XRCC2.
Mohamed Ragab Abdel Gawwad, Mohamed Soliman Elshikh, Haris Lokvancic   +2 more
doaj  

Accessing DNA damage in chromatin: Preparing the chromatin landscape for base excision repair

, 2015
DNA damage in chromatin comes in many forms, including single base lesions that induce base excision repair (BER). We and others have shown that the structural location of DNA lesions within nucleosomes greatly influences their accessibility to repair ...
Rodriguez, Yesenia, Hinz, John M, Smerdon, Michael J   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Enzymes DNA Repair in Skin Photoprotection: Strategies Counteracting Skin Cancer Development and Photoaging Strategies

Cosmetics
Ultraviolet radiation (UVR) is a major contributor to skin aging and carcinogenesis, primarily through the induction of DNA damage. While conventional sunscreens provide passive protection by blocking UVR, active photoprotection using DNA repair enzymes ...
Ewelina Musielak, Violetta Krajka-Kuźniak   +1 more
doaj   +1 more source