Results 91 to 100 of about 219,333 (243)

Recognition of a Clickable Abasic Site Analog by DNA Polymerases and DNA Repair Enzymes. [PDF]

Int J Mol Sci, 2022
Endutkin AV, Yudkina AV, Zharkov TD, Kim DV, Zharkov DO.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases. [PDF]

Basic Clin Pharmacol Toxicol, 2022
Karsten S.
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Apoptotic vesicles are required to repair DNA damage and suppress premature cellular senescence

Journal of Extracellular Vesicles
It is well known that DNA damage can cause apoptosis. However, whether apoptosis and its metabolites contribute to DNA repair is largely unknown. In this study, we found that apoptosis‐deficient Fasmut and Bim−/− mice show significantly elevated DNA ...
Zhiqing Huang, Yuzhi Zhuang, Wenwen Li, Mingchen Ma, Fangcao Lei, Yan Qu, Jiaqi Li, Huigen Luo, Changzheng Li, Lu Lu, Lan Ma, Xiao Zhang, Xiaoxing Kou, Linjia Jiang, Xueli Mao, Songtao Shi   +15 more
doaj   +1 more source

DNA Repair Enzymes in Prevention of Photocarcinogenesis [PDF]

Photochemistry and Photobiology, 1996
D B, Yarosh, J, Klein
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Escherichia coli induces DNA repair enzymes to protect itself from low-grade hydrogen peroxide stress. [PDF]

Mol Microbiol, 2022
Gupta A, Imlay JA.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Exploring DNA Damage and Repair Mechanisms: A Review with Computational Insights

BioTech
DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related disorders.
Jiawei Chen, Ravi Potlapalli, Heng Quan, Lingtao Chen, Ying Xie, Seyedamin Pouriyeh, Nazmus Sakib, Lichao Liu, Yixin Xie   +8 more
doaj   +1 more source