Results 111 to 120 of about 376,771 (302)

Cytosine-to-Uracil Deamination by SssI DNA Methyltransferase [PDF]

, 2013
The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
A Beletskii, A Jeltsch, AN Sharath, Antal Kiss, AS Yang, B Bandaru, B Bandaru, B Chaikind, BM Hall, BTF van der Gun, DM Woodcock, EA Raleigh, EU Selker, EV Koudan, G Pósfai, GL Xu, H Gowher, I Stier, Ildikó Stier, J Sambrook, JC Shen, JC Shen, JC Shen, JM Zingg, JM Zingg, KM Reinisch, LA Frederico, LM Guzman, M Frommer, M Wyszynski, Martin G. Marinus, MH Sibley, P Rathert, P Renbaum, PA Waite-Rees, PM Warnecke, R Métivier, R Shapiro, RJ Roberts, RY-H Wang, S Kumar, SE Luria, T Durfee, TA Kunkel, UT Sankpal, WA Rosche, X Cheng, X Zhang   +47 more
core   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CONTRIBUTION OF DNA REPAIR ENZYMES GENES POLYMORPHISM TO CHROMOSOMAL MUTAGENESIS IN HUMAN LYMPHOCYTES (REVIEW)

Вестник Кемеровского государственного университета, 2013
A review of scientific publications on the analysis of the correlation between chromosome aberrations and DNA repair enzymes genes polymorphism in healthy individuals and cancer patients is provided.
V. I. Minina
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Protein–Protein Interactions in Base Excision Repair

Biomolecules
The Base Excision Repair (BER) pathway involves a highly coordinated series of protein–protein interactions that facilitate the recognition, excision, and repair of damaged bases. Key enzymes such as DNA glycosylases, apurinic/apyrimidinic endonuclease 1
Govardhan Rathnaiah, Joann B. Sweasy
doaj   +1 more source

Interactome analysis and docking site prediction of DNA X-ray repair cross-complementing protein (XRCC) in Arabidopsis thaliana [PDF]

Network Biology, 2020
There are seven homologs in eukaryotic RAD51 gene family which are conserved among animals and plants, and those are RAD51, DMC1, RAD51c, XRCC3, RAD51b, RAD51d and XRCC2.
Mohamed Ragab Abdel Gawwad, Mohamed Soliman Elshikh, Haris Lokvancic   +2 more
doaj  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Enzymes DNA Repair in Skin Photoprotection: Strategies Counteracting Skin Cancer Development and Photoaging Strategies

Cosmetics
Ultraviolet radiation (UVR) is a major contributor to skin aging and carcinogenesis, primarily through the induction of DNA damage. While conventional sunscreens provide passive protection by blocking UVR, active photoprotection using DNA repair enzymes ...
Ewelina Musielak, Violetta Krajka-Kuźniak   +1 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source