Results 131 to 140 of about 376,771 (302)

Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases. [PDF]

Basic Clin Pharmacol Toxicol, 2022
Karsten S.
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Apoptotic vesicles are required to repair DNA damage and suppress premature cellular senescence

Journal of Extracellular Vesicles
It is well known that DNA damage can cause apoptosis. However, whether apoptosis and its metabolites contribute to DNA repair is largely unknown. In this study, we found that apoptosis‐deficient Fasmut and Bim−/− mice show significantly elevated DNA ...
Zhiqing Huang, Yuzhi Zhuang, Wenwen Li, Mingchen Ma, Fangcao Lei, Yan Qu, Jiaqi Li, Huigen Luo, Changzheng Li, Lu Lu, Lan Ma, Xiao Zhang, Xiaoxing Kou, Linjia Jiang, Xueli Mao, Songtao Shi   +15 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Escherichia coli induces DNA repair enzymes to protect itself from low-grade hydrogen peroxide stress. [PDF]

Mol Microbiol, 2022
Gupta A, Imlay JA.
europepmc   +1 more source

Cell Death Response to DNA Damage. [PDF]

, 2019
The cell death response to DNA damage is discussed in this Perspectives piece with cancer as the backdrop because DNA damaging agents (DDA) are widely used to treat cancer.
Wang, Jean YJ
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Sequence Dependent Repair of 1,N⁶-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB. [PDF]

Molecules, 2021
Qi R, Bian K, Chen F, Tang Q, Zhou X, Li D.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

[DNA repair enzymes and their genes].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1998
DNA repair is of fundamental importance for protection of the genetic material against mutations in an interplay with mechanisms that regulate the cell cycle, gene expression, and programmed cell death. Defects in DNA repair, or in processes in tegrated with DNA repair, may give cells a hyper mutable phenotype that increases the likelihood of mutations
H E, Krokan, G, Slupphaug
openaire   +1 more source