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Base excision repair and the role of
Hereditary Cancer in Clinical Practice, 2007 The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development.
Kairupan Carla, Scott Rodney J
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Protein–Protein Interactions in Base Excision Repair [PDF]
BiomoleculesThe Base Excision Repair (BER) pathway involves a highly coordinated series of protein–protein interactions that facilitate the recognition, excision, and repair of damaged bases. Key enzymes such as DNA glycosylases, apurinic/apyrimidinic endonuclease 1
Govardhan Rathnaiah, Joann B. Sweasy
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Cancer prognosis using base excision repair genes [PDF]
Molecules and Cells: The base excision repair (BER) pathway is a critical mechanism in genomic stability. This review investigates the role of the BER pathway in advanced cancer therapies considering the pivotal role of genetic factors in cancer patient responses and ...
Jeongeun Kim +4 more
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Altered Mitochondrial Base Excision Repair and Mitochondrial DNA Instability in Peripheral Leukocytes of Patients with MASLD [PDF]
CellsMetabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial metabolic disorder that is strongly associated with mitochondrial dysfunction and oxidative stress, which may potentially compromise the integrity of mitochondrial DNA ...
Sylwia Ziółkowska +10 more
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Base excision and nucleotide excision repair pathways in mycobacteria
Tuberculosis, 2011 About a third of the human population is estimated to be infected with Mycobacterium tuberculosis. The bacterium displays an excellent adaptability to survive within the host macrophages. As the reactive environment of macrophages is capable of inducing DNA damage, the ability of the pathogen to safeguard its DNA against the damage is of paramount ...
Kurthkoti, Krishna, Varshney, Umesh
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A Rule-Based Model of Base Excision Repair [PDF]
, 2014 There are ongoing debates in the DNA repair community on whether the coordination of DNA repair is achieved by means of direct protein-protein interactions or whether substrate specificity is sufficient to explain how DNA intermediates are channeled from one repair enzyme to the other. In order to address these questions we designed a model of the Base
Köhler, Agnes +2 more
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Base excision repair in sugarcane [PDF]
Genetics and Molecular Biology, 2001 DNA damage can be induced by a large number of physical and chemical agents from the environment as well as compounds produced by cellular metabolism.
Agnez-Lima Lucymara F. +3 more
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Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy [PDF]
CellsGenomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in ...
Anna Piscone +6 more
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Bacillus Calmette-Guerin Increases Base Excision Repair in Bladder Cancer Cells [PDF]
Journal of Urological Surgery, 2021 Objective:Most patients with non-muscle-invasive bladder cancer (NMIBC) do not respond to intravesical Bacillus Calmette-Guerin (BCG) immunotherapy and have high risk of NMIBC recurrence and progression.
Selçuk Keskin +2 more
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Dynamic features of human mitochondrial DNA maintenance and transcription
Frontiers in Cell and Developmental Biology, 2022 Mitochondria are the primary sites for cellular energy production and are required for many essential cellular processes. Mitochondrial DNA (mtDNA) is a 16.6 kb circular DNA molecule that encodes only 13 gene products of the approximately 90 different ...
Mansour Akbari +4 more
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