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Protein–Protein Interactions in Base Excision Repair [PDF]
BiomoleculesThe Base Excision Repair (BER) pathway involves a highly coordinated series of protein–protein interactions that facilitate the recognition, excision, and repair of damaged bases. Key enzymes such as DNA glycosylases, apurinic/apyrimidinic endonuclease 1
Govardhan Rathnaiah, Joann B. Sweasy
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Base excision repair and the role of
Hereditary Cancer in Clinical Practice, 2007 The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development.
Kairupan Carla, Scott Rodney J
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Base excision repair and cancer [PDF]
Cancer Letters, 2012 Base excision repair is the system used from bacteria to man to remove the tens of thousands of endogenous DNA damages produced daily in each human cell. Base excision repair is required for normal mammalian development and defects have been associated with neurological disorders and cancer.
Susan S Wallace +2 more
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Cancer prognosis using base excision repair genes [PDF]
Molecules and Cells: The base excision repair (BER) pathway is a critical mechanism in genomic stability. This review investigates the role of the BER pathway in advanced cancer therapies considering the pivotal role of genetic factors in cancer patient responses and ...
Jeongeun Kim +4 more
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Base excision repair in sugarcane [PDF]
Genetics and Molecular Biology, 2001 DNA damage can be induced by a large number of physical and chemical agents from the environment as well as compounds produced by cellular metabolism.
Agnez-Lima Lucymara F. +3 more
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A role for p53 in base excision repair [PDF]
EMBO Journal, 2001 Wild-type p53 protein can markedly stimulate base excision repair (BER) in vitro, either reconstituted with purified components or in extracts of cells. In contrast, p53 with missense mutations either at hot-spots in the core domain or within the N-terminal transactivation domain is defective in this function.
Samuel Wilson, Jinwoo Ahn, C Prives
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Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy [PDF]
CellsGenomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in ...
Anna Piscone +6 more
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Dynamic features of human mitochondrial DNA maintenance and transcription
Frontiers in Cell and Developmental Biology, 2022 Mitochondria are the primary sites for cellular energy production and are required for many essential cellular processes. Mitochondrial DNA (mtDNA) is a 16.6 kb circular DNA molecule that encodes only 13 gene products of the approximately 90 different ...
Mansour Akbari +4 more
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Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function. [PDF]
PLoS ONE, 2015 The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all ...
Zhi Liu +6 more
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Cold Spring Harbor Perspectives in Biology, 2013 Base excision repair (BER) corrects DNA damage from oxidation, deamination and alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is initiated by a DNA glycosylase that recognizes and removes the damaged base, leaving an abasic site that is further processed by short-patch repair or long-patch repair that largely uses
Hans E, Krokan, Magnar, Bjørås
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