Results 101 to 110 of about 47,675 (279)
Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source
Expanding Radical Chloropentafluorosulfanylation of Alkynes
The chloropentafluorosulfanylation of alkynes is a delicate but crucial operation for accessing SF5-alkynes that serve as substrates in numerous transformations. Dolbier’s procedure using Et3B/O2 was the most efficient approach, while recent efforts make
Thi Mo Nguyen (9378926) +5 more
core +1 more source
Advanced Science, EarlyView.AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang +19 more
wiley +1 more source
Chemoselectivity in Gold(I)-Catalyzed Propargyl Ester Reactions: Insights From DFT Calculations
Frontiers in Chemistry, 2019 Au-catalyzed propargyl ester reactions have been investigated by a comprehensive density functional theory (DFT) study. Our calculations explain the experimental observed chemoselectivity of Au-catalyzed propargyl ester reactions very well by considering
Qing Sun +5 more
doaj +1 more source
Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing
Advanced Science, EarlyView.A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi +8 more
wiley +1 more source
Nature CommunicationsCarboxylation with CO2 offers an attractive and sustainable access to valuable carboxylic acids. Among these methods, direct C−H carboxylation of terminal alkynes with CO2 has attracted much attention for one-carbon homologation of alkynes, enabling ...
Jin-Cheng Xu +8 more
doaj +1 more source
Gold-Catalyzed Synthesis of 2-Sulfenylspiroindolenines via Spirocyclizations
Molbank, 2018 2-Phenylsulfenyl-N-propargyl tryptamines have been prepared by electrophilic sulfuration of the corresponding tryptamines. These compounds undergo gold-catalyzed spirocyclizations to the corresponding 2-phenylthiospiroindolenines in good yields.
Valentin Magné +4 more
doaj +1 more source
The Direct Conversion of α‑Hydroxyketones to Alkynes
, 2019 Alkynes are highly important functional groups in organic chemistry, both as part of target structures and as versatile synthetic intermediates. In this study, a protocol for the direct conversion of α-hydroxyketones to alkynes is reported.
Lukas Nattmann (5854907) +3 more
core +1 more source
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Functional group tolerant iron-catalyzed cyclotrimerization of terminal and internal alkynes
Communications ChemistryArenes play a crucial role in various fields of chemistry. Since Kekulé proposed the molecular structure of benzene in 1865, chemists have been working to develop methods for preparing functionalized arenes.
Benedict Klinnert, Bernd Plietker
doaj +1 more source