Results 131 to 140 of about 21,779,284 (300)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

All-cause death in the entire and propensity-matched populations.

open access: yes, 2019
All-cause death in the entire and propensity-matched populations.
Seung-Hwa Lee (5900741)   +6 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

All-cause mortality associated with MS and its individual components.

open access: yes, 2016
All-cause mortality associated with MS and its individual components.
Zhixia Li (2736331)   +6 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

All-cause and cardiovascular mortality associated with oral mucosal lesions.

open access: yes, 2019
All-cause and cardiovascular mortality associated with oral mucosal lesions.
Marietta Török (3168186)   +25 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The Breakfast Club

open access: yes, 2013
The Breakfast Club was set up in January 2013. The aim of the breakfast club is to provide pupils with breakfast in a safe, structured and warm environment at the beginning of each school day so as to enhance their - Concentration- Attendance and ...
Healthy Food For All
core   +1 more source

Sarcopenia Associated with All-Cause Mortality Risk

open access: yesJournal of the College of Physicians and Surgeons Pakistan
To examine the association of sarcopenia with elevated all-cause mortality risk.Descriptive study. Place and Duration of the Study: Department of Endocrinology, the First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Hubei, China, from December 2024 to April 2025.Data were obtained from 11,176 ...
Shuping, Zhang, Zhaoyang, Zeng
openaire   +2 more sources

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