Results 131 to 140 of about 20,400,894 (307)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mortality from asthma and COPD in Australia [PDF]

, 2014
This report provides information about mortality due to asthma and chronic obstructive pulmonary disease (COPD) in Australia, examining trends over time, seasonal variation, international comparison and variation by age, sex, remoteness, Indigenous ...

core  

All-cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan Cohort [PDF]

We aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death‐cause data from BioBank Japan, with baseline years 2003–2007.
オオオカ, タダオ, 25509, 40422688, Hirata, Makoto, 30790175, Yokomichi, Hiroshi, 大岡, 忠生, Ooka, Tadao, 24695, 24631, 23302, Horiuchi, Sayaka, 24118, Nagai, Akiko, コジマ, レイジ, Miyake, Kunio, 秋山, 有佳, 24294, アキヤマ, ユウカ, Akiyama, Yuka, BionBank Japan Project, 20596879, ホリウチ, サヤカ, 10523780, 堀内, 清華, ミヤケ, クニオ, Kojima, Reiji, ヤマガタ, ゼンタロウ, ヨコミチ, ヒロシ, 60550712, 24901, 横道, 洋司, 10210337, 00807646, 篠原, 亮次, 25512, Yamagata, Zentaro, 25511, 望月, 美恵, 40803987, 00633116, 山縣, 然太朗, Mochizuki, Mie, モチヅキ, ミエ, 小島, 令嗣, シノハラ, リョウジ, 三宅, 邦夫, Shinohara, Ryoji   +47 more
core   +1 more source

Haemodynamically irrelevant pericardial effusion is associated with increased mortality in maintenance hemodialysis patients with end-stage renal disease

BMC Nephrology
Background Pericardial effusion (PE) is common in patients with end-stage renal disease (ESRD) undergoing maintenance haemodialysis (MHD). The prognostic value of a small, haemodynamically non-compromising PE in patients with ESRD who undergo MHD, is ...
Lizheng Song, Jian Chen, Junwei Xu, Liyun Luo, Mei Xu, Wenyi Tang, Yuxi Huang, Hsi Huang, Man Li, Jianting Ke   +9 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Prognosis of early‐stage HFpEF in the community‐dwelling elderly: The Northern Shanghai Study

ESC Heart Failure
Objective Heart failure with preserved ejection fraction (HFpEF) is a growing concern among the elderly population, significantly impacting morbidity and mortality rates.
Weilun Meng, Haotian Yang, Zhongyuan Ren, Jiawen Wu, Yixing Zheng, Song Zhao, Chong Xu, Rusitanmujiang Maimaitiaili, Jiamin Tang, Shikai Yu, Jing Xiong, Chen Chi, Yawei Xu, Yi Zhang   +13 more
doaj   +1 more source

Temporal Trends in Mortality and Hospitalization Risk in Patients With Heart Failure According to the Hospital Frailty Risk Score

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Heart failure (HF) and frailty often coexist. However, it is unknown how the interplay between HF and frailty at HF onset impacts prognosis of frail patients with HF and how this has evolved over time. Methods and Results We identified 131 235
Noor K. Abassi, Nina Nouhravesh, Mariam Elmegaard, Marte Austreim, Deewa Zahir, Caroline Hartwell Garred, Jawad H. Butt, Camilla Fuchs Andersen, Jarl E. Strange, Caroline Sindet‐Pedersen, Daniel M. Christensen, Emil Fosbøl, Charlotte Andersson, Lars Køber, Morten Schou   +14 more
doaj   +1 more source