Results 121 to 130 of about 2,170,657 (312)
Therapeutics and Clinical Risk Management, 2020 Zhongying Zhang,1 Xiang Gu,2 Xianghua Fang,3 Zhe Tang,4 Shaochen Guan,3 Hongjun Liu,3 Xiaoguang Wu,3 Chunxiu Wang,3 Yan Zhao5 1Geriatric Department, Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s ...
Zhang Z +8 more
doaj
Results and observations from the reconstruction of continuous time series of mortality by cause of death [PDF]
Though many countries have been collecting cause-of-death information from death certificates for more than a century, these valuable data sources remain underexplored.
Markéta Pechholdová
core
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 [PDF]
Background: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (
Mario D'Oria +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Infant death investigation : guidelines for the scene investigator [PDF]
The Guidelines for the Scene Investigator is a 39-page, 5x7 informational handbook that guides investigators in conducting an infant death investigation using recommended practices.
core
Mortality from asthma and COPD in Australia [PDF]
, 2014 This report provides information about mortality due to asthma and chronic obstructive pulmonary disease (COPD) in Australia, examining trends over time, seasonal variation, international comparison and variation by age, sex, remoteness, Indigenous ...
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Reviews in Cardiovascular MedicineBackground: Despite advances in treatment and the potential role of serum albumin as a prognostic biomarker, the mortality rate of individuals with coronary heart disease (CHD) continues to increase.
Jiayi Tong +6 more
doaj +1 more source
Cause of fetal death : data from the Fetal Death Report, 2014 [PDF]
Objectives: This report presents, for the first time, data on cause of fetal death by selected characteristics such as maternal age, Hispanic origin and race, fetal sex, period of gestation, and birthweight.Methods: Descriptive tabulations of data ...
core