Results 101 to 110 of about 2,170,657 (312)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effect of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation: A retrospective cohort study

Annals of Noninvasive Electrocardiology
Objective To explore the influence of nutritional status on adverse clinical events in elderly patients with nonvalvular atrial fibrillation. Methods This retrospective observational cohort study included 196 patients, 75–102‐years‐old, with nonvalvular ...
Kan Zhang, Ying Sun, Jiancao Ding, Qing Ma, Dai Zhang, Wei Huang, Yunli Xing   +6 more
doaj   +1 more source

Cause-of-death data [PDF]

In an earlier note, the value and limitations of mortality data as measures of the health status of a community were discussed. The purpose of this Sixth Note is to extend that discussion and deal specifically with the usefulness to health planners of ...

core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Educational differences in all-cause mortality by marital status [PDF]

Using life table measures, we compare educational differentials in all-cause mortality at ages 40 to 70 in Bulgaria to those in Finland and the United States. Specifically, we assess whether the relationship between education and mortality is modified by
Pekka Martikainen, Irma Elo, Iliana V. Kohler, Kirsten P. Smith   +3 more
core  

Systematic review and meta-analysis of reduction in all-cause mortality from walking and cycling and shape of dose response relationship [PDF]

, 2014
Background and objectiveWalking and cycling have shown beneficial effects on population risk of all-cause mortality (ACM). This paper aims to review the evidence and quantify these effects, adjusted for other physical activity (PA).Data sourcesWe ...
Thomas Götschi, Foster, C, Scarborough, Peter, Kahlmeier, Sonja, Nia Roberts, Goetschi, T, Götschi, Thomas, Paul Kelly, Scarborough, P, Orsini, Nicola, Richards, Justin, Kahlmeier, S, Richards, J, Charlie Foster, Götschi, T, Foster, Charlie, Orsini, N,, Sonja Kahlmeier, Nicola Orsini, Peter Scarborough, Roberts, N, Foster, Charles, Orsini, N, Kelly, Paul, Roberts, Nia, Justin Richards, Kelly, P   +26 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Risk prediction models for mortality in patients with cardiovascular disease: The BioBank Japan project

Journal of Epidemiology, 2017
Background: Cardiovascular disease (CVD) is a leading cause of death in Japan. The present study aimed to develop new risk prediction models for long-term risks of all-cause and cardiovascular death in patients with chronic phase CVD. Methods: Among the
Jun Hata
doaj   +1 more source

Leading Causes of Death and All-Cause Mortality in American Indians and Alaska Natives

American Journal of Public Health, 2014
Objectives. We present regional patterns and trends in all-cause mortality and leading causes of death in American Indians and Alaska Natives (AI/ANs). Methods. US National Death Index records were linked with Indian Health Service (IHS) registration records to identify AI/AN deaths misclassified as non-AI/AN.
David K, Espey, Melissa A, Jim, Nathaniel, Cobb, Michael, Bartholomew, Tom, Becker, Don, Haverkamp, Marcus, Plescia   +6 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source