Results 81 to 90 of about 2,170,657 (312)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Correlation Between Low Serum T3 Levels and All-Cause and Cardiovascular Mortality in Peritoneal Dialysis Patients

Therapeutics and Clinical Risk Management, 2021
Ling-Cang Xu,1,2 Fang-Fang Zhou,1,2 Meng Li,1,2 Zhi-Wei Dai,1,2 Ke-Dan Cai,1,2 Bei-Xia Zhu,1,2 Qun Luo1,2 1Department of Nephrology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang Province, 315010, People’s Republic of ...
Xu LC, Zhou FF, Li M, Dai ZW, Cai KD, Zhu BX, Luo Q   +6 more
doaj  

All-Cause Mortality and Specific Causes of Death in Autism: A Nationwide Analysis

Autism in Adulthood
Background: Western studies have reported a higher mortality risk in autistic individuals. However, the specific causes of death and the roles of age, sex, and concurrent intellectual disability (ID) remain unclear. This study aimed to analyze the causes of death in autism and the moderating effects of age, sex,
Wu, Chi-Shin, Tsai, Hui-Ju, Chien, Yi-Ling, Gau, Susan Shur-Fen   +3 more
openaire   +2 more sources

Risk stratification for death and all-cause hospitalization in heart failure clinic outpatients [PDF]

American Heart Journal, 2013
Most heart failure (HF) risk stratification models were developed for inpatient use, and available outpatient models use a complex set of variables. We hypothesized that routinely collected clinical data could predict the 6-month risk of death and all-cause medical hospitalization in HF clinic outpatients.Using a quality improvement database and ...
Scott L, Hummel, Hussam H, Ghalib, David, Ratz, Todd M, Koelling   +3 more
openaire   +2 more sources

Underlying Cause of Death Recorded during 2013 to 2015 at a Tertiary General Hospital in Vientiane Capital, Lao PDR [PDF]

, 2017
2017-05In Lao People’s Democratic Republic (Lao PDR), the cause of death is not registered in death reports. As a result, the government cannot produce official reports that show mortality according to cause of death.
Manivon, Tavanh, Hamajima, Nobuyuki, Phoummalaysith, Bounfeng, Louangpradith, Viengsakhone, Yamamoto, Eiko, Keohavong, Bounxou   +5 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Comparison of physician-certified verbal autopsy with computer-coded verbal autopsy for cause of death assignment in hospitalized patients in low- and middle-income countries : systematic review [PDF]

, 2014
BACKGROUND: Computer-coded verbal autopsy (CCVA) methods to assign causes of death (CODs) for medically unattended deaths have been proposed as an alternative to physician-certified verbal autopsy (PCVA).
Leitao, Jordana, Suraweera, Wilson, Tollman, Stephen, Tollman, Stephen,, Pierre Miasnikof, Aleksandrowicz, Lukasz, Lu, Ying, Dewan Alam, Prabhat Jha, Abhishek Singh, Jha, Prabhat, Nikita Desai, Desai, Nikita, Miasnikof, Pierre, Faujdar Ram, Ram, Faujdar, Byass, Peter, Lukasz Aleksandrowicz, Alam, Dewan, Peter Byass, Singh, Abhishek, Stephen Tollman, Ying Lu, Wilson Suraweera, Jordana Leitao, Byass, Peter,, Suresh Kumar Rathi, Rathi, Suresh Kumar   +27 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source