Results 61 to 70 of about 2,584,847 (299)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The association of cold weather and all-cause and cause-specific mortality in the island of Ireland between 1984 and 2007 [PDF]

, 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
A Analitis, A Atsumi, AG Barnett, AG Barnett, AG Barnett, AJ McMichael, AL Braga, Ariana Zeka, B Revich, BG Anderson, C Liddell, CB Field, D Levy, GC Donaldson, H McAvoy, Helen McAvoy, I Gemmell, J Diaz, J Schwartz, J Schwartz, J Schwartz, J Schwartz, JD Healy, JD Healy, JP Buckley, JT Lee, K Ebi, M Carder, M Maclure, ME Payton, MS Goldberg, P Goodman, Patrick Goodman, PG Goodman, PL Kinney, PL Staddon, R Walker, S Hajat, Stephen Browne, T Lumley, TF Bateson, TF Bateson, The Marmot Review Team, U Dubois, W Yu, Y Guo, Y Lu, YC Hong   +47 more
core   +3 more sources

Clinical profile, treatment, and outcomes of febrile neutropenia in hematologic disorders: a look at 30-day mortality predictors

Scientific Reports
Patients with hematologic malignancies are susceptible to neutropenic fever, a potentially life-threatening condition. This study investigated the association between clinical profiles, treatment, and outcomes in these patients.
Eskedar Ferdu Azerefegne, Gebeyehu Tessema Azibte, Fitsum Seyoum Bekele, Kehabtimer Shiferaw Kotiso, Berhanu Moges Abera, Bereket Abraha Molla, Yonatan Habtamu Tamene, Wondwossen Amogne Degu   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics: A Study with the General Practice Research Database. [PDF]

, 2013
Objective. Assess risk of cardiac events and mortality among users of olanzapine and other antipsychotics relative to nonusers. Methods. The General Practice Research Database was used to identify cohorts of antipsychotic users and nonusers with ...
Brunner, Elizabeth, Campbell, Giedra, Jones, Meghan E, Motsko, Stephen, Murray-Thomas, Tarita, Patel, Deven, Shatapathy, Chetan C, Van Staa, Tjeerd, van Staa, Tjeerd P   +8 more
core   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The Association Between Urinary Genistein Levels and Mortality Among Adults in the United States [PDF]

, 2019
BackgroundCurrent research on the relationship between phytoestrogens and mortality has been inconclusive. We explored the relationship between genistein, a phytoestrogen, and mortality in a large cohort representative of the United States population ...
Marcelo, Carolyn, Marcelo, Catherine, Qayyum, Rehan, Warwick, Melissa   +3 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Associations between fine and coarse particles and mortality in Mediterranean cities: results from the MED-PARTICLES project [PDF]

, 2013
Few studies have investigated the independent health effects of different size fractions of particulate matter (PM) in multiple locations, especially in Europe. We estimated the short-term effects of PM with aerodynamic diameter = 10 µm (PM10), = 2.5 µm
Agis Cherta, David, Alessandrini, Ester, Declercq, Christophe, Díaz, Julio, Forastiere, Francesco, Karanasiou, Angeliki, Katsouyanni, Klea, Kelessis, Apostolos G., Le Tertre, Alain, Ostro, Bart, Pandolfi, Paolo, Randi, Giorgia, Rodopoulou, Sophia, Samoli, Evangelia, Scarinzi, Cecilia, Stafoggia, Massimo, Study Group, MED-PARTICLES, Zauli-Sajani, Stefano   +17 more
core   +2 more sources

A cohort study on the correlation between serum Klotho levels and all-cause mortality in American diabetic populations

Diabetology & Metabolic Syndrome
Background The global prevalence of diabetes is on an upward trajectory. The management of complications related to the condition has seen limited progress in recent years.
Kangxiang Wu, Jiaqi Chen, Yiying Lin, Jie Wang   +3 more
doaj   +1 more source