Results 61 to 70 of about 16,019,830 (296)

Low-Voltage Mixed-Mode Analog Filter Using Multiple-Input Multiple-Output Operational Transconductance Amplifiers

IEEE Access
This paper presents a novel mixed-mode, low-power, 1 V analog filter that uses multiple-input multiple-output operational transconductance amplifiers (MIMO-OTAs).
Montree Kumngern, Fabian Khateb, Tomasz Kulej   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Electronically Tunable Mixed-Mode Universal Filter Employing a Single Active Block and a Minimum Number of Passive Components

Applied Sciences, 2020
A recently developed active building block, namely Voltage Differencing Extra X Current Conveyor (VD-EXCCII), is employed in the design of multi input single output (MISO), electronically tunable mixed-mode universal filter. The filter provides low pass (
Mohammad Faseehuddin, Norbert Herencsar, Musa Ali Albrni, Jahariah Sampe   +3 more
doaj   +1 more source

Factorized All-Pass Based IIR Adaptive Notch Filters

IEEE Transactions on Signal Processing, 2007
This paper introduces a new family of infinite impulse response adaptive notch filters that forms multiple notches using a second-order factorization of an all-pass transfer function. The new orthogonal realization is amenable for adaptive filtering to obtain the unknown frequencies of interest.
Juan E. Cousseau, Stefan Werner 0001, Pedro D. Doñate   +2 more
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Self-Coupled Optical Waveguide-Based Tunable Photonic Structure for Spectral Control and Transmission Response Simulation

Engineering Proceedings
We propose a novel self-coupled optical waveguide (SCOW+) architecture that enhances spectral control in integrated photonic circuits. Derived from the foundational SCOW platform, SCOW+ introduces a tunable ring resonator coupled with an all-pass filter ...
Charmaine C. Paglinawan, Arnold C. Paglinawan, Benjamin B. Dingel, Gwen G. Evangelista   +3 more
doaj   +1 more source

A NEW CURRENT TUNABLE CURRENT INPUT CURRENT OUTPUT BIQUAD USING CFTAS [PDF]

Journal of Engineering Science and Technology, 2017
A new current-tunable current input current output universal biquad circuit synthesized with three current follower trans-conductance amplifiers (CFTAs) and two grounded capacitors is presented in this paper. The proposed circuit simultaneously, realizes
S. V. SINGH, R. S. TOMAR, D. S. CHAUHAN
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source