Results 71 to 80 of about 15,533,381 (158)
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller +14 more
wiley +1 more source
Grants Pass Notice of Adopted Amendment (2008-05-19)
, 2008 22 pp. Adopted 2008-05-19. Department of Land Conservation and Development Notice of Adopted AmendmentAmend the Grants Pass Comprehensive Plan Map for two parcels from Medium Density Residential (MDR) to High-Rise Density Residential (HDR) and the zone ...
Grants Pass (Or.)
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Realization of separable nth order 2D all-pass digital filters
, 1992 The realization, circuit and state space of two-dimensional (2D) nth order separable all-pass digital filters is considered. The matrices A, b, c′ and the scalar d of the Givone-Roesser state space model are presented in closed form. The dimension of the
Antoniou, G. E. +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie +8 more
wiley +1 more source
Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias +3 more
wiley +1 more source
IDEOLOG: A Program for Filtering Econometric Data - A Synopsis of Alternative Methods [PDF]
An account is given of various filtering procedures that have been implemented in a computer program, which can be used in analysing econometric time series.
D.S.G. Pollock
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu +7 more
wiley +1 more source
An algorithm for the optimization of adjustable fractional-delay all-pass filters
, 2004 This paper considers optimizing adjustable fractional-delay (FD) all-pass filters in the minimax sense. A filter structure proposed by Makundi, Laakso, and Välimäki and referred to as an all-pass gathering structure is employed.
Tapio Saramäki, Juha Yli-Kaakinen
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