Results 91 to 100 of about 13,324 (245)

Advanced therapy medicinal products (ATMPs) – An analysis of the global regulatory status

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background A rapid progress in the development of advanced therapy medicinal products (ATMPs) has taken place over the past decades. The ATMPs hold great potential but face challenges in the clinical development and the regulatory process.
Allan Cramer, Freja Karuna Hemmingsen Sørup, Marie Lund, Tonny Studsgaard Petersen, Kristian Karstoft   +4 more
wiley   +1 more source

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan, Christopher Banfield, Kenneth Hung, Anna Sapone, Vivek Pradhan, Yuxi Zhao, Dana Parsons‐Rich, Grace Lee, Bryce G. Johnson, Elena Peeva, Michael S. Vincent, Valerie M. Clerin   +11 more
wiley   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source

Strategies teachers use to support students' self‐regulation skill development in mainstream primary schools: A scoping review

British Educational Research Journal, EarlyView.
Abstract This scoping review has explored the interventions and approaches used by teachers in mainstream (general education) primary schools (students aged 4–11) to support self‐regulation skill development in the classroom. The review followed the PRISMA Extension for Scoping Reviews (PRISMA‐ScR) guidelines for reporting and was guided by the Joanna ...
Kim Griffin, Kate Wilmut, Carol Brown, Tanya Rihtman   +3 more
wiley   +1 more source

Development of an Indirect Photoacoustic Sensor Concept for Highly Accurate Low-ppm Gas Detection

Proceedings
Indirect photoacoustic sensing (PAS) offers accurate low-ppm gas measurements, with an inverse relation of the obtained signal to the measured gas concentration. The gas is sealed in transistor outline (TO) housing using a new method.
Ananya Srivastava, Achim Bittner, Alfons Dehé   +2 more
doaj   +1 more source

Spatial metrics in fire ecology: seeking consistency amidst complexity

Biological Reviews, EarlyView.
ABSTRACT Technological advances, including remote sensing, have led to a proliferation of metrics used in ecological studies to examine spatial patterns of fire regimes and their ecological effects. Researchers can use many different metrics to analyse spatial variation in both fire events and resulting fire regimes, including fire size, shape ...
Alexander R. Carey, Geoffrey J. Cary, Teigan Cremona, Hugh F. Davies, Brett P. Murphy, Sam C. Banks   +5 more
wiley   +1 more source

Extent, characteristics and policy applications of Key Biodiversity Areas

Biological Reviews, EarlyView.
ABSTRACT A global standard for the identification of Key Biodiversity Areas (KBAs) was published 10 years ago to provide a unified set of criteria for identifying ‘sites of significance for the global persistence of biodiversity’. We review the initiative's origins, the KBA identification process, characteristics of the current network, threats, policy
Stuart H. M. Butchart, Olivia Crowe, Tom Scott, Andrew J. Plumptre, Megan Eldred, Ellen McKee, Zoltan Waliczky, Ibrahim Al Hasani, Adrián B. Azpiroz, Daniele Baisero, Fred Barasa, Alison E. Beresford, Bezeng S. Bezeng, Charlotte Boyd, Thomas M. Brooks, Graeme Buchanan, Gill Bunting, Sofia Capellan, Neil Cox, Tim R. B. Davenport, Tammy E. Davies, Gina Della Togna, Wendy Elliott, Matt Foster, Jo Gilbert, Jonathan M. Handley, Diego Juffe‐Bignoli, Victoria R. Jones, Naomi Kingston, Jeannot Kivono, John Lamoreux, Penny F. Langhammer, James Lewis, Bruce Liggitt, Daniel Marnewick, Paul Matiku, Erin McCreless, Rachel A. Neugarten, Catherine Numa, Mark O'Brien, Madhu Rao, Ciara Raudsepp‐Hearne, Justina C. Ray, Samridhi Rijal, Jon Paul Rodríguez, Jurgis Sapijanskas, Wes Sechrest, Martin Sneary, Andrew Snyder, Konstantina Spiliopoulou, Thomas Starnes, Cecilia Tobar, Gautam Surya, Marcelo F. Tognelli, Andrew W. Tordoff, Maria G. Toscano, Yongyut Trisurat, Amy Upgren   +57 more
wiley   +1 more source

A Decision‐Making Model for Implementing Green Technology in Sustainable Building Projects

Business Strategy and the Environment, EarlyView.
ABSTRACT Green technology (GT) adoption is pivotal for reconciling environmental stewardship with economic viability in the built environment, particularly in resource‐constrained emerging economies. However, empirical evidence on how specific GT drivers actively mitigate adoption barriers remains scarce.
Abdelazim Ibrahim, Ahmed Farouk Kineber, Ayodeji Emmanuel Oke, Mehrdad Arashpour, M. K. S. Al‐Mhdawi, Abe Abimbola Maxwell   +5 more
wiley   +1 more source

Temperature-dependent mechanical losses of Eu3+:Y2SiO5 for spectral hole burning laser stabilization

APL Materials
We investigate the mechanical loss characteristics of Eu3+:Y2SiO5—a promising candidate for ultra-low-noise frequency stabilization through the spectral hole burning technique.
Nico Wagner, Michael T. Hartman, Bess Fang, Johannes Dickmann, Stefanie Kroker   +4 more
doaj   +1 more source

Climate Change Risk and Financial Stability: Implications for European Banking Institutions

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines whether climate change risk weakens banking‐system stability in the European Union and assesses how renewable energy adoption and energy‐related taxation moderate this relationship. Using panel data for 27 EU countries from 2012 to 2022 and applying fixed‐effects OLS, two‐stage least squares (2SLS), and robust generalized ...
Md Yousuf Ali
wiley   +1 more source