Results 191 to 200 of about 1,163,092 (332)

Modeling Control of Invasive Fire Ants by Gene Drive

Advanced Science, EarlyView.
The fire ant Solenopsis invicta is characterized by exceptional invasive capabilities, rendering conventional control ineffective. Here, we explore the use of homing suppression gene drive in fire ants by developing a spatially explicit model. Overall, these results show that target population suppression requires an extended time scale, but that gene ...
Yiran Liu, Samuel E. Champer, Benjamin C. Haller, Jackson Champer   +3 more
wiley   +1 more source

Natural Selection of a Virus-Protective FUT2 Variant Following the Transition to Agriculture. [PDF]

Mol Biol Evol
Nordgren J, Ågren R, Hu DZ, Neijd M, Childebayeva A, Prüfer K, Hagbom M, Svensson L, Zeberg H.   +8 more
europepmc   +1 more source

RESPONSES OF ESTERASE 6 ALLELES OF DROSOPHILA MELANOGASTER AND D. SIMULANS TO SELECTION IN EXPERIMENTAL POPULATIONS

, 1966
Ross J Mac Intyre, Theodore R. F. Wright
openalex   +2 more sources

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men. [PDF]

Genome Med
Mendoza-Mejía N, Kolbe D, Özer O, Dose J, Torres GG, Franke A, Nygaard M, Nebel A.   +7 more
europepmc   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Genotyping short tandem repeats across copy number alterations, aneuploidies, and polyploid organisms. [PDF]

Commun Biol
Verbiest MA, Grassi E, Bertotti A, Anisimova M.   +3 more
europepmc   +1 more source

INCREMENT OF AVERAGE FITNESS FOR MULTIPLE ALLELES [PDF]

, 1969
C. C. Li
openalex   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

Allele-specific genomics decodes gene targets and mechanisms of the non-coding genome. [PDF]

Nucleic Acids Res
Hasenbein TP, Hoelzl S, Engelhardt S, Andergassen D.   +3 more
europepmc   +1 more source