Results 1 to 10 of about 387,087 (317)

Idiosyncratic Drug-Induced Liver Injury: From Pathogenesis to Risk Reduction

Безопасность и риск фармакотерапии, 2023
Idiosyncratic drug-induced liver injury (iDILI) is a rare and poorly predictable adverse drug reaction that may lead to death or liver transplantation in severe cases.The aim of the study was to review contemporary concepts of the immune-mediated ...
I. A. Mazerkina
doaj   +1 more source

A simple PCR-SSP method for detection of HLA-B*15:02, *15:13, and *15:21

Türk Biyokimya Dergisi, 2023
This study aims to develop a simple polymerase chain reaction (PCR) sequence-specific primer method, which will be used to genotype HLA-B*15:02, HLA-B*15:13, and HLA-B*15:21.
Musa Nurfadhlina, Govindasamy G. Saravana, Hoong Chew Beng, Annuar Aziati Azwari, Mohamed Noor Dzul Azri, Daud Nur Aizati Athirah   +5 more
doaj   +1 more source

Distribution patterns of HLA-A^*, B^*, DRB1^* allele groups among persons who underwent COVID-19

Медицинская иммунология, 2021
The main histocompatibility complex — HLA system (Human Leukocyte Antigens) is among the most important genetic factors determining response of humans to infectious agents.
L. N. Bubnova, I. E. Pavlova, A. S. Berkos, M. A. Terentyeva, T. V. Glazanova, L. V. Erokhina, E. V. Belyaeva, A. V. Chechetkin, N. S. Bashketova, I. G. Chkhindzheria, M. А. Kozhemyakina, D. V. Azarov, R. N. Kuznetsova, Areg A. Totolyan   +13 more
doaj   +1 more source

L´association entre les gènes HLA II et la susceptibilité à l´asthme chez une population Constantinoise sélectionnée

The Pan African Medical Journal, 2020
INTRODUCTION: L´asthme est une maladie complexe causé par l´interaction de plusieurs gènes dont certains ont un effet protecteur et d´autres contribuent à l´apparition de la maladie.
Dahbia Ines Dahmani, Nacima Chila, Fouzia Abdelouahab, Houda Bouyoucef, Mohamed Bougrida, Laila Rouabah, Fayssal Nedjar   +6 more
doaj   +1 more source

De Novo donor-specific anti-HLA antibody risk stratification in kidney transplantation using a combination of B cell and T cell molecular mismatch assessment

Frontiers in Immunology
IntroductionThe presence of de novo donor-specific antibody (dnDSA) has detrimental effect on allograft outcomes in kidney transplantation. As humoral responses in transplantation are elicited targeting non-self-epitopes on donor HLA proteins, assessing ...
Elaine Chou-Wu, Matthias Niemann, Danny Youngs, Idoia Gimferrer   +3 more
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Beyond HLA: an exploratory pilot study of non-HLA antibodies, HLA sensitization, and GSTT1 genotype in platelet transfusion refractoriness

Frontiers in Immunology
ObjectivesPlatelet transfusion refractoriness (PTR) is a common and clinically challenging condition with complex underlying mechanisms. Human leukocyte antigen (HLA) alloimmunization is the principal cause of immune PTR (iPTR), whereas non-HLA ...
Jun Qi, Huachao Zhu, Manni Wang, Tianju Wang, Yuhui Li, Lixia Shang, Le Chen, Xiaofang Wang, Jing Shao, Chaofeng Ma, Hua Xu   +10 more
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NGS identifies novel HLA-DQA1 and DPB1 associations with aplastic anemia in the Kazakhstani population

Frontiers in Immunology
BackgroundAplastic anemia (AA) is a rare but serious blood disorder defined by autoimmune-driven destruction of bone marrow stem and progenitor cells.
Aida Turganbekova, Aida Turganbekova, Zhulduz Zhanzakova, Perizat Kanabekova, Dana Baimukasheva, Zhazira Saduakas, Didara Khamitova, Saniya Abdrakhmanova, Zhaksylyk Masalimov, Wassim Y. Almawi   +9 more
doaj   +1 more source

A generic RNA pulsed DC based approach for developing therapeutic intervention against nasopharyngeal carcinoma

Human Vaccines & Immunotherapeutics, 2017
The recurrent nasopharyngeal carcinoma of head-and-neck cancers pathology showed unique symptoms and clinical characteristics. The complexity of pathology poses challenges for developing therapeutic interventional approaches against nasopharyngeal ...
Rajeev K. Tyagi, Rajesh Parmar, Naisargee Patel   +2 more
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SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA

Медицинская иммунология, 2014
. The aim of this work was to reveal novel criteria for prediction of clinical course in myasthenia, based on immunogenetic characteristics of the patients.
L. N. Bubnova, I. E. Pavlova, V. V. Baranov, N. M. Zhulev   +3 more
doaj   +1 more source

Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response

OncoImmunology, 2021
The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy.
Dhon Roméo Makanga, Maxime Jullien, Gaëlle David, Nolwenn Legrand, Catherine Willem, Léa Dubreuil, Alexandre Walencik, Cyrille Touzeau, Thomas Gastinne, Benoit Tessoulin, Steven Le Gouill, Béatrice Mahé, Katia Gagne, Patrice Chevallier, Béatrice Clemenceau, Christelle Retière   +15 more
doaj   +1 more source