Results 1 to 10 of about 593,053 (260)

NGS identifies novel HLA-DQA1 and DPB1 associations with aplastic anemia in the Kazakhstani population

Frontiers in Immunology
BackgroundAplastic anemia (AA) is a rare but serious blood disorder defined by autoimmune-driven destruction of bone marrow stem and progenitor cells.
Aida Turganbekova, Aida Turganbekova, Zhulduz Zhanzakova, Perizat Kanabekova, Dana Baimukasheva, Zhazira Saduakas, Didara Khamitova, Saniya Abdrakhmanova, Zhaksylyk Masalimov, Wassim Y. Almawi   +9 more
doaj   +1 more source

Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study [PDF]

, 2005
Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle.
Almeida, C., Mallal, S., Martin, A., McKinnon, E., Nolan, D., Rauch, A.   +5 more
core   +2 more sources

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]

, 2020
ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco, Cole, Robert N, Darrah, Erika, Fava, Andrea, Guhr, Tara, McMahan, Zsuzsanna H, O'Meally, Robert N, Shah, Ami A, Tiniakou, Eleni, Wigley, Fredrick M   +9 more
core   +1 more source

The economic implications of HLA matching in cadaveric renal transplantation. [PDF]

, 1999
Background: The potential economic effects of the allocation of cadaveric kidneys on the basis of tissue-matching criteria are controversial. We analyzed the economic costs associated with the transplantation of cadaveric kidneys with various numbers of ...
Brennan, Daniel C, Cohen, David S, Hollenbeak, Christopher S, Howard, Todd K, Lowell, Jeffrey A, Mohanakumar, T, Schnitzler, Mark A, Singer, Gary G, Tesi, Raymond J, Woodward, Robert   +9 more
core   +2 more sources

A generic RNA pulsed DC based approach for developing therapeutic intervention against nasopharyngeal carcinoma

Human Vaccines & Immunotherapeutics, 2017
The recurrent nasopharyngeal carcinoma of head-and-neck cancers pathology showed unique symptoms and clinical characteristics. The complexity of pathology poses challenges for developing therapeutic interventional approaches against nasopharyngeal ...
Rajeev K. Tyagi, Rajesh Parmar, Naisargee Patel   +2 more
doaj   +1 more source

SIGNIFICANCE OF IMMUNOGENETIC PREDISPOSAL FOR CLINICAL COURSE OF MYASTHENIA

Медицинская иммунология, 2014
. The aim of this work was to reveal novel criteria for prediction of clinical course in myasthenia, based on immunogenetic characteristics of the patients.
L. N. Bubnova, I. E. Pavlova, V. V. Baranov, N. M. Zhulev   +3 more
doaj   +1 more source

Assessing the utilization of high-resolution 2-field HLA typing in solid organ transplantation. [PDF]

, 2019
HLA typing in solid organ transplantation (SOT) is necessary for determining HLA-matching status between donor-recipient pairs and assessing patients\u27 anti-HLA antibody profiles.
Dinh, Anh, Duke, Jamie L., Ferriola, Deborah, Frackelton, Edward C., Gasiewski, Allison, Geier, Steven S., Heron, Steven, Huang, Yanping, Kentzel, Ethan, Kneib, Carolina, Mehler, Hilary, Mignogno, Michael T., Monos, Dimitri, Morlen, Ryan, Mosbruger, Timothy, Slavich, Larissa, Timofeeva, Olga A.   +16 more
core   +1 more source

Real-Time Distributed Aircraft Simulation through HLA [PDF]

, 2012
This paper presents some ongoing researches carried out in the context of the PRISE (Research Platform for Embedded Systems Engineering) Project. This platform has been designed to evaluate and validate new embedded system concepts and techniques through
Chaudron, Jean-Baptiste, Gervais, Clément, Leconte, Régine, Saussié, David, Siron, Pierre   +4 more
core   +1 more source

Association of HLA-C*07:359 with HLA-A, -B, and -DRB1 alleles in Taiwanese

Tzu Chi Medical Journal
Objectives: It is thought that Taiwanese indigenous people were the “first people” to populate Taiwan (Formosa) having been there for over 5000 years, preceding the Dutch colonization (from 1624 to 1662) and Spanish colonization (from 1626 to 1642 ...
Kuo-Liang Yang, Py-Yu Lin
doaj   +1 more source