Results 201 to 210 of about 1,186,851 (331)

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Genetic Risk Factors for Poor Cognitive Outcome Following Brain Insult-A Systematic Review. [PDF]

Brain Behav
Dunås T, Leiss S, Corell A, Skoglund T, Dénes A, Carén H, Smits A, Rydén I, Jakola A.   +8 more
europepmc   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Genetic Diversity of <i>Plasmodium falciparum</i> Merozoite Surface Protein 1 and 2 Genes and Their Allele Association With Malaria Severity, Seasons, and Sex in Bamenda, North West Cameroon. [PDF]

Can J Infect Dis Med Microbiol
Achungu CR, Anong DN, Faustin K, Shey RA, Tabe CJ, Djouosseu CA.   +5 more
europepmc   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Gene Flooding: Proposal to Flood Invasive Populations With Inbred Individuals as a Form of Low-Tech Genetic Control. [PDF]

Ecol Evol
Gould J, Beranek C.
europepmc   +1 more source

Association between HLA-DQB1, -DPB1 alleles and risk of carbamazepine-induced hypersensitivity reactions in Vietnamese patients with epilepsy

Thi Thanh Nhan Le, Thi Tu Linh Nguyen, Phuong Lan Le, Doan Thuy Nguyen, Van Lieu Nguyen, Thi Van Anh Nguyen, Hong Thai Trinh   +6 more
openalex   +2 more sources

B_x, Another Allele of the ABO Locus and its Heredity

, 1964
Hideo Yamaguchi, Yasuto Okubo, Fumio Hazama, Shizuo OYAMA   +3 more
openalex   +2 more sources

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

The RNA-binding protein HuR modulates the expression of the disease-linked <i>CCL2</i> rs1024611G-rs13900T haplotype. [PDF]

Elife
Akhtar F, Ruiz JH, Liu YG, Resendez RG, Feliers D, Morales LD, Diaz-Badillo A, Lehman DM, Arya R, Alvarenga JCL, Blangero J, Duggirala R, Mummidi S.   +12 more
europepmc   +1 more source