Results 211 to 220 of about 1,163,092 (332)

Engineered crRNA Drives RPA‐T7‐CRISPR/Cas14a Cascade for Ultrasensitive Detection of ctDNA PIK3CA H1047R

Advanced Science, EarlyView.
The TIDE‐Cas14a system, an integrated RPA‐T7‐CRISPR/Cas14a cascade platform incorporating engineered crRNA mismatches, enables ultrasensitive detection of the PIK3CA H1047R mutation in breast cancer circulating tumor DNA, with a limit of detection as low as 0.01%, surpassing the sensitivity of droplet digital PCR.
Yuanyuan Yu, Mengru Jin, Weiguang Yuan, Yajie Gong, Siwei Li, Xuquan Qin, Jianxun Hou, Jialin Liu, Siyu Liu, Hui Li, Yijun Chu, Yingjie Wang, Youxue Zhang, Fang Fang, Wenhui Hao, Yuling Gu, Qinchen Fan, Jing Lin, Da Pang, Xianyu Zhang   +19 more
wiley   +1 more source

Quantitative and large-scale investigation of human TCR-HLA cross-reactivity. [PDF]

Sci Adv
Pan M, Tan Y, Wang YT, Hu J, Fleming J, Hu H, Yang Z, Zhan X, Li B.   +8 more
europepmc   +1 more source

VARIATION IN PARAMUTABILITY OF Rr IN MAIZE FOLLOWING EXTRACTION OF THE ALLELE FROM A LINKED RECIPROCAL TRANSLOCATION

, 1966
Dale E. Kester, R. A. Brink
openalex   +2 more sources

ALLELE SPECIFIC DETERMINANTS OF HOMOTHALLISM IN SACCHAROMYCES LACTIS [PDF]

, 1966
A. I. Herman, Herschel Roman
openalex   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Association of a Novel IgG3 Allele With Malaria in Children From the Sepik Region of Papua New Guinea. [PDF]

J Infect Dis
Saeed M, Aitken EH, Naung MT, Bourke C, Wu KW, Longley RJ, Chung AW, Damelang T, Kiniboro B, Mueller I, Rogerson SJ.   +10 more
europepmc   +1 more source

Complementation and recombination between Methionine-2 alleles in Neurospora crassa [PDF]

, 1960
Noreen E. Murray
openalex   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Gender-Specific Next-Generation Sequencing Reveals First Allelic Variation Patterns in Dementia Risk Among Bangladeshis: The CARED Study. [PDF]

Int J Gen Med
Ranjan R, Yusuf MA, Uddin MN, Mamun MT, Mamun AA, Kawnayn G, Hakim M.   +6 more
europepmc   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source