Results 231 to 240 of about 818,935 (300)

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

PolyAdapt: Characterizing Polygenic Adaptive Architectures in the Presence of Strong Linkage Disequilibrium. [PDF]

Genome Biol Evol
Mazzucco R, Schlötterer C.
europepmc   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Ultrarapid MC1R protein and associated plumage color evolution in the domestic chicken. [PDF]

Proc Natl Acad Sci U S A
Ma C, Liebing AD, Kleinau G, Kamprad A, Calabrese L, Szczepek M, Li Z, Larsson M, Scheerer P, Stäubert C, Andersson L.   +10 more
europepmc   +1 more source

Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice

Advanced Science, EarlyView.
This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang, Zhengting Chen, Pengxiang Bai, Biao Liu, Lingling Meng, Jian Zhang, Xu Li, Dao‐Xiu Zhou, Xuan Ma, Yu Zhao   +9 more
wiley   +1 more source

Erratum: Corrigendum: Generation of a <i>C. elegans tdp-1</i> null allele and humanized <i>TARDBP</i> containing human disease-variants. [PDF]

MicroPubl Biol
europepmc   +1 more source

Genetic Variability in the IGF-1 Axis Modulates Cancer-Associated Cachexia and Prognosis. [PDF]

Cancers (Basel)
Moreira Pires M, Guerra de Melo I, Silva ACL, Rocha Dias V, Silva C, Silva MP, M O Santos J, Ferreira T, Tavares V, Medeiros R.   +9 more
europepmc   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Maternal Genetic Variants and Gestational Duration: A Replication Study in a Japanese Cohort. [PDF]

J Clin Med
Tanabu R, Iino K, Sato M, Nakamura M, Yokoyama M, Tamada Y, Itoh K, Mikami T, Murashita K, Yokoyama Y.   +9 more
europepmc   +1 more source