Results 251 to 260 of about 1,186,851 (331)

Weight-loss effects of macronutrient-based diets modified by genetic variants: a protocol for systematic review of randomised controlled trials. [PDF]

BMJ Open
Subardjo YP, Khairunnissa NM, Kusuma RJ, Huriyati E, Susetyowati S.   +4 more
europepmc   +1 more source

Structural Variation and 3D Genome‐Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication

Advanced Science, EarlyView.
These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao, Shangkun Jin, Haojie Jiang, Tianyu Pan, Zesheng Rui, Xiaowen Shi, Ting Zhao, Zhanfeng Si, Xueying Guan, Yan Hu, Tianzhen Zhang, Lei Fang   +11 more
wiley   +1 more source

Discovery and validation of ASG1 as a novel determinant of NaCl tolerance in the yeast Saccharomyces cerevisiae through iterative crossing. [PDF]

G3 (Bethesda)
Žun G, Petrovič U.
europepmc   +1 more source

Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles

, 2010
Fumiaki Tanaka, Ken Yamamoto, Sadao Suzuki, Hiromasa Inoue, Masahiko Tsurumaru, Yoshiaki Kajiyama, Hoichi Kato, Hiroyasu Igaki, Koh Furuta, Hiromasa Fujita, Toru Tanaka, Yoïchi Tanaka, Y Kawashima, Shoji Natsugoe, Tetsuro Setoyama, Shinkan Tokudome, Koshi Mimori, Naoki Haraguchi, Hideshi Ishii, Masaki Mori   +19 more
openalex   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

A genome-wide association study reveals additive and recessive alleles affecting male fertility in pigs. [PDF]

J Anim Sci Biotechnol
Sá P, Gòdia M, Godinho RM, Sevillano CA, Harlizius B, Madsen O, Bovenhuis H.   +6 more
europepmc   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Genome-wide selection inference at short tandem repeats. [PDF]

PLoS Genet
Huang B, Durvasula A, Mousavi N, Ziaei-Jam H, Maksimov M, Lohmueller KE, Gymrek M.   +6 more
europepmc   +1 more source

Impact of HLA Allele Mismatch at HLA-A, -B, -C, and -DRB1 in Single Cord Blood Transplantation

, 2019
Hisayuki Yokoyama, Yasuo Morishima, Shigeo Fuji, Naoyuki Uchida, Satoshi Takahashi, Makoto Onizuka, Masatsugu Tanaka, Yuju Ohno, Tetsuya Eto, Yukiyasu Ozawa, Satoru Takada, Minoko Takanashi, Koji Kato, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Junya Kanda   +16 more
openalex   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source