Results 291 to 300 of about 1,408,208 (397)

FTO and NOS3 genes associated with pediatric obesity: Corações de Ouro Preto study. [PDF]

open access: yesBMC Pediatr
Batista AP   +12 more
europepmc   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

open access: yesAdvanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan   +11 more
wiley   +1 more source

Cytochrome P450 2C19 Genotypes and Clopidogrel in Patients With Ischemic Stroke: A Nonrandomized Clinical Trial.

open access: yesJAMA Netw Open
Jung YH   +16 more
europepmc   +1 more source

Critical assessment of missense variant effect predictors on disease-relevant variant data. [PDF]

open access: yesHum Genet
Rastogi R   +35 more
europepmc   +1 more source

Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism

open access: yesAdvanced Science, EarlyView.
Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley   +1 more source

The Transcription Factor WFZP Interacts with the Chromatin Remodeler TaSYD to Regulate Root Architecture and Nitrogen Uptake Efficiency in Wheat

open access: yesAdvanced Science, EarlyView.
Root development and nitrogen uptake efficiency are vital for crop productivity. Du, Li, Jiang, et al. show that the wheat transcription factor WFZP and the chromatin remodeler TaSYD form a complex within the nucleus, thereby activating the expression of genes associated with root development and nitrate transporters, ultimately enhancing both root ...
Dejie Du   +18 more
wiley   +1 more source

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