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2011
Methods of estimating allele frequencies from data on unrelated and related individuals are described in this chapter. For samples of unrelated individuals with simple codominant markers, the natural estimator of allele frequencies can be used. For genetic data on related individuals, maximum likelihood estimation (MLE) can be applied to compute allele
Indra, Adrianto, Courtney, Montgomery
openaire +3 more sources
Methods of estimating allele frequencies from data on unrelated and related individuals are described in this chapter. For samples of unrelated individuals with simple codominant markers, the natural estimator of allele frequencies can be used. For genetic data on related individuals, maximum likelihood estimation (MLE) can be applied to compute allele
Indra, Adrianto, Courtney, Montgomery
openaire +3 more sources
Annual Review of Genomics and Human Genetics, 2000
The age of an allele can be estimated both from genetic variation among different copies (intra-allelic variation) and from its frequency. Estimates based on intra-allelic variation follow from the exponential decay of linkage disequilibrium because of recombination and mutation.
M, Slatkin, B, Rannala
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The age of an allele can be estimated both from genetic variation among different copies (intra-allelic variation) and from its frequency. Estimates based on intra-allelic variation follow from the exponential decay of linkage disequilibrium because of recombination and mutation.
M, Slatkin, B, Rannala
openaire +2 more sources
Single-cell RNA counting at allele and isoform resolution using Smart-seq3
Nature Biotechnology, 2020Michael Hagemann-Jensen +2 more
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