Results 1 to 10 of about 539,301 (229)

Non-equilibrium theory of the allele frequency spectrum [PDF]

Theoretical Population Biology, 2007
A forward diffusion equation describing the evolution of the allele frequency spectrum is presented. The influx of mutations is accounted for by imposing a suitable boundary condition. For a Wright-Fisher diffusion with or without selection and varying population size, the boundary condition is $\lim_{x \downarrow 0} x f(x,t)= (t)$, where $f(\cdot,t)
Montgomery Slatkin, Yelena Shvets, Steven N. Evans   +2 more
openaire   +7 more sources

Kernel density estimation of allele frequency including undetected alleles. [PDF]

PeerJ
Whereas undetected species contribute to estimation of species diversity, undetected alleles have not been used to estimated genetic diversity. Although random sampling guarantees unbiased estimation of allele frequency and genetic diversity measures, using undetected alleles may provide biased but more precise estimators useful for conservation.
Aoki S, Fukasawa K.
europepmc   +4 more sources

Allele Frequencies Database [PDF]

Transfusion Medicine and Hemotherapy, 2014
This review describes a database for the collection, archiving, sorting, searching and display of gene and allele frequencies for immunogenetic genes.
Faviel F. Gonzalez-Galarza, Louise Y. Takeshita, Andrew R. Jones, Derek Middleton   +3 more
openaire   +3 more sources

Warmblood fragile foal syndrome type 1 mutation (PLOD1 c.2032G>A) is not associated with catastrophic breakdown and has a low allele frequency in the Thoroughbred breed. [PDF]

, 2020
BackgroundCatastrophic fractures are among the most common cause of fatalities in racehorses. Several factors, including genetics, likely contribute to increased risk for fatal injuries.
Arthur, R, Bellone, RR, Finno, CJ, Hughes, SS, Le, V, Ocampo, NR, Penedo, MCT   +6 more
core   +1 more source

Wright-Fisher diffusion bridges [PDF]

, 2017
{\bf Abstract} The trajectory of the frequency of an allele which begins at $x$ at time $0$ and is known to have frequency $z$ at time $T$ can be modelled by the bridge process of the Wright-Fisher diffusion.
Griffiths, Robert, Jenkins, Paul A., Spanò, Dario   +2 more
core   +2 more sources

Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage. [PDF]

, 2019
One fundamental but understudied mechanism of gene regulation in disease is allele-specific expression (ASE), the preferential expression of one allele.
A Chess, A de la Chapelle, A Gimelbrant, A Hogart, A McKenna, A Mortazavi, AA Adegbola, AL Oberg, AM Veerappa, B DeVeale, B Howie, B Langmead, B Tycko, C Fuchsberger, C Gicquel, C Gregg, C Lee, CA de Leeuw, CCY Wong, Changhoon Lee, Cross-Disorder Group of the Psychiatric Genomics Consortium., D Kim, Daniel H. Geschwind, DH Geschwind, E Ben-David, E Eden, E Eden, E Gardiner, EH Cook Jr., Eleazar Eskin, EM Quinn, Eun Yong Kang, EY Kang, F Supek, GT Consortium, GV Kryukov, H Li, HA Scoles, I Iossifov, I Voineagu, J Cavaille, J Cavaille, J Grove, JC Darnell, JF Degner, JK Pickrell, KR Kukurba, M Elsabbagh, M Meguro-Horike, Michael J. Gandal, N Mukherjee, NN Parikshak, NN Parikshak, PH Sudmant, PS Bazeley, R Karlic, S Anders, S Kehr, S Kishore, S Nardone, S Purcell, Schizophrenia Working Group of the Psychiatric Genomics Consortium., SE Castel, SJ Sanders, SM Weyn-Vanhentenryck, T Hulsen, V Savova, Y Zhang, YE Wu   +68 more
core   +1 more source

Selection Mapping Identifies Loci Underpinning Autumn Dormancy in Alfalfa (Medicago sativa). [PDF]

, 2018
Autumn dormancy in alfalfa (Medicago sativa) is associated with agronomically important traits including regrowth rate, maturity, and winter survival. Historical recurrent selection experiments have been able to manipulate the dormancy response.
Brummer, E Charles, Hao, Jingjie, Munjal, Gitanshu, Teuber, Larry R   +3 more
core   +3 more sources

Signatures of introgression across the allele frequency spectrum [PDF]

Molecular Biology and Evolution, 2020
ABSTRCTThe detection of introgression from genomic data is transforming our view of species and the origins of adaptive variation. Among the most widely used approaches to detect introgression is the so-called ABBA BABA test orDstatistic, which identifies excess allele sharing between non-sister taxa.
Simon H. Martin, William Amos
openaire   +5 more sources

Brief communication: Evolution of a specific O allele (O1vG542A) supports unique ancestry of Native Americans [PDF]

, 2013
In this study, we explore the geographic and temporal distribution of a unique variant of the O blood group allele called O1vG542A, which has been shown to be shared among Native Americans but is rare in other populations.
, , , Achilli, Acuna-Alonzo, Bolnick, Bortolini, Campbell, Chester, Crawford, Dulik, Dulik, Eshleman, Estrada-Mena, Fagundes, Fagundes, Gagneux, Gardner, Georges, Greenberg, Halverson, Hummel, Hunemeier, Johnson, Jurmain, Karafet, Karafet, Karafet, Kemp, Kemp, Kemp, Kitchen, Lell, Lell, Llop, Malhi, Molnar, Mourant, Mulligan, Nichols, Perego, Perego, Reich, Schroeder, Schroeder, Schurr, Smith, Swerdlow, Szathmary, Tamm, Underhill, Vajda, Yip, Yip, Yip, Zegura   +55 more
core   +4 more sources

Estimation of allele frequencies at isoloci. [PDF]

Genetics, 1988
Abstract In some polyploid animals and plants, pairs of duplicated loci occur that share alleles encoding proteins with identical electrophoretic mobilities. Except in cases where these "isoloci" are known to be inherited tetrasomically, individual genotypes cannot be determined unambiguously, and there is no direct way to assign ...
openaire   +3 more sources