Results 241 to 250 of about 595,057 (344)

Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines. [PDF]

Am J Hum Genet
Saitou M, Dahl A, Wang Q, Liu X.
europepmc   +1 more source

Characterization of the full site frequency spectrum of GWAS risk alleles in psychiatric disorders

, 2020
Dmytro Pravdyvets
openalex   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Estimation of cell variant frequency (CVF) from variant allele frequency (VAF).

Yilun Ji (6569438), Xiaonan Chen (3181938), Xiaohui Zhang (81778), Wenjing Wang (181404), Lan Xue (1966738), Yifan Zhong (6115982), Dacheng Tian (32387), Sihai Yang (32385), Long Wang (95893), Milton Brian Traw (10345006), Ju Huang (806291)   +10 more
openalex   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Frequency of *4 allele in CYP2D6 gene and its Association with Ovarian Cancer Risk in Tehran, Iran

, 2016
S H Helalat, Kh Onsory, Zahra Nouri
openalex   +1 more source

Results for ADAMIXTURE: Ancestry Proportions ($Q$) and Allele Frequencies ($P$) on Simulated and Public Empirical Datasets

Joan Saurina i Ricós, Daniel Mas Montserrat, Alexander G. Ioannidis   +2 more
openalex   +1 more source

Benchmarking autosomal recessive disease prevalence estimation from allele frequencies against newborn screening data [PDF]

Michael C. Sierant, Nicholas Knoblauch, Evan Witt, Daniel J. Gaffney, Sara L. Pulit, Arthur Wüster   +5 more
openalex   +1 more source

Compartmentalized Homeostasis Drives High Bamboo Forest Productivity under Nutrient Imbalance

Advanced Science, EarlyView.
This study reveals how Moso bamboo achieves high productivity despite nutrient‐poor soils. It employs a unique strategy, maintaining strict nutrient balance in its leaves while using woody tissues as flexible storage reservoirs. This compartmentalized mechanism buffers the plant from soil phosphorus limitation and microbial competition, resolving the ...
Zhikang Wang, Quan Li, Man Shi, Marcio F.A. Leite, Xinli Chen, Eiko E. Kuramae, Viviane Cordovez, Tingting Cao, Chenglei Zhu, Libin Zhou, Wenjuan Yu, Zhiyao Tang, Changhui Peng, Xinzhang Song   +13 more
wiley   +1 more source

Allele frequency of genetic variations related to the <i>UGT1A1</i> gene-drug pair in a group of Iranian population. [PDF]

J Diabetes Metab Disord
Sarhangi N, Fahimfar N, Rouhollah F, Sharifi F, Bidkhori M, Nikfar S, Ostovar A, Nabipour I, Patrinos GP, Hasanzad M.   +9 more
europepmc   +1 more source