Results 21 to 30 of about 451,573 (269)

Genome-Wide Screening for SNPs Associated with Stature in Diverse Cattle Breeds

Biology and Life Sciences Forum, 2022
Cattle breeds used in industrial production tend to have a larger size compared to the local cattle, as the increased dairy and beef productivity is closely related to the stature. The aim of our work was to identify single nucleotide polymorphisms (SNPs)
Alexandra S. Abdelmanova, Alexander A. Sermyagin, Arsen V. Dotsev, Nikolay V. Bardukov, Margaret S. Fornara, Gottfried Brem, Natalia A. Zinovieva   +6 more
doaj   +1 more source

Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022
Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino, Neus Falgàs, Isabel E. Allen, Mircea Balasa, Jaume Olives, José Contador, Magdalena Castellví, Jordi Juncà‐Parella, Núria Guillén, Sergi Borrego‐Écija, Bea Bosch, Guadalupe Fernández‐Villullas, Oscar Ramos‐Campoy, Anna Antonell, Lorena Rami, Raquel Sánchez‐Valle, Albert Lladó   +16 more
wiley   +1 more source

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers, Shanice Beerepoot, Ingeborg Krägeloh‐Mann, Saskia Elgün, Benjamin Bender, Marjo S. van der Knaap, Nicole I. Wolf, Samuel Groeschel   +7 more
wiley   +1 more source

Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population

BMC Medical Genetics, 2018
Background Rheumatic heart disease (RHD) is an autoimmune disease triggered by acute rheumatic fever (ARF). Matrix metalloproteinases (MMPs) play an important role in the modulation of immune responses.
Wei Hu, Yujia Ye, Yirui Yin, Peng Sang, Linhua Li, Jing Wang, Wen Wan, Rui Li, Xiangfeng Bai, Yuehui Xie, Zhaohui Meng   +10 more
doaj   +1 more source

Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population

Annals of Human Biology, 2022
Primary lactose malabsorption is characterised by a down-regulation of lactase activity after weaning and inability to digest lactose in adulthood. It has been suggested that the historical introduction of dairying led to a positive selection for lactase
Stefan Németh, Gernot Kriegshäuser, Kristine Hovhannesyan, Hasmik Hayrapetyan, Christian Oberkanins, Tamara Sarkisian   +5 more
doaj   +1 more source

Genomic polymorphism in tribal population of Tripura: Signifying their closer affinity with the Nepalese and Tibetan populations

Annals of Human Biology, 2021
Background India is the second most populous country in the world, which is aligned into various community segments. Aim To evaluate the genetic diversity of the tribal population of Tripura, we carried out this study.
Subhankar Nath, Pankaj Shrivastava, R. K. Kumawat, Shivani Dixit, Gyaneshwer Chaubey   +4 more
doaj   +1 more source

A Population Study: HLA-A, -B, -C, -DRB1, -DQB1, -DQA1 Alleles, and ABDR Haplotype Frequencies in the Aegean Region of Türkiye

Forbes Tıp Dergisi
Objective: Human leukocyte anti-gen (HLA) molecules are vital molecules because they present foreign anti-gens to immune cells and trigger the immune response.
Aslı ÖZKIZILCIK KOÇYİĞİT, Tülay KILIÇASLAN AYNA, Mustafa SOYÖZ, Burcu ÇERÇİ ALKAÇ, Rasime Derya GÜLEÇ, Deniz İlhan TOPÇU, İbrahim PİRİM   +6 more
doaj   +1 more source

Genetic diversity through human leukocyte antigen typing in end-stage renal disease patients and prospective donors of North India

Indian Journal of Pathology and Microbiology, 2016
As the incidence of end-stage renal disease (ESRD) is rapidly increasing, the demand for dialysis and transplantation has dramatically increased, which has led to concerns about the availability and equitable allocation of kidneys for transplantation ...
Mohit Chowdhry, Raj Nath Makroo, Manoj Kumar   +2 more
doaj   +1 more source

Evidence for selection on SARS-CoV-2 RNA translation revealed by the evolutionary dynamics of mutations in UTRs and CDSs

RNA Biology, 2022
RNA translation is the rate-limiting step when cells synthesize proteins. Elevating translation efficiency (TE) is intuitively beneficial. Particularly, when viruses invade host cells, how to compete with endogenous RNAs for efficient translation is a ...
Lin Zhu, Qi Wang, Weiyu Zhang, Hao Hu, Kexin Xu   +4 more
doaj   +1 more source

Patterns of neutral diversity under general models of selective sweeps [PDF]

Genetics September 1, 2012 vol. 192 no. 1 205-224, 2011
Two major sources of stochasticity in the dynamics of neutral alleles result from resampling of finite populations (genetic drift) and the random genetic background of nearby selected alleles on which the neutral alleles are found (linked selection). There is now good evidence that linked selection plays an important role in shaping polymorphism levels
arxiv   +1 more source