Results 101 to 110 of about 1,221,818 (402)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Genetic resources of local chicken in Georgia

Біологія тварин
The preservation of local poultry gene fund has both scientific and practical importance for Georgia. High genetic potential is important for breeders from national, state, scientific and economic points of view. It has been determined by scientists that
Anatoli Giorgadze, Marine Barvenashvili
doaj   +1 more source

Why Mutant Allele Frequencies in Oncogenes Peak Around 0.40 and Rapidly Decrease? [PDF]

arXiv, 2016
The mutant allele frequencies in oncogenes peak around 0.40 and rapidly decrease. In this article, we explain why this is the case. Invoking a key result from mathematical analysis in our model, namely, the inverse function theorem, we estimate the selection pressures of the mutations as a function of germline allele frequencies.
arxiv  

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

, 2018
Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely ...
Anmole, G., Brockman, M., Chopera, D., Goering, E., Ismail, N., Mann, J., Miller, R., Muema, D., Ndhlovu, Z., Ndung'u, T., Nkosi, T., Ogunshola, F.   +11 more
core   +2 more sources

The effect of sheltered load on reproduction in Solanum carolinense, a species with variable self-incompatibility [PDF]

, 2009
In previous studies, we have investigated the strength of self-incompatibility (SI) in Solanum carolinense, a highly successful weed with a fully functional SI system that inhabits early successional and other disturbed habitats.
Keser, L.H., Mena-Ali, J.I., Stephenson, A.G.   +2 more
core   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Bayesian inference of natural selection from allele frequency time series [PDF]

arXiv, 2016
The advent of accessible ancient DNA technology now allows the direct ascertainment of allele frequencies in ancestral populations, thereby enabling the use of allele frequency time series to detect and estimate natural selection. Such direct observations of allele frequency dynamics are expected to be more powerful than inferences made using patterns ...
arxiv  

ADZE: a rarefaction approach for counting alleles private to combinations of populations

Bioinform., 2008
Motivation: Analysis of the distribution of alleles across populations is a useful tool for examining population diversity and relationships. However, sample sizes often differ across populations, sometimes making it difficult to assess allelic ...
Zachary A. Szpiech, M. Jakobsson, N. Rosenberg   +2 more
semanticscholar   +1 more source

A Phylogenetic Analysis of the Genus Fragaria (Strawberry) Using Intron-Containing Sequence from the ADH-1 Gene [PDF]

, 2014
The genus Fragaria encompasses species at ploidy levels ranging from diploid to decaploid. The cultivated strawberry, Fragaria×ananassa, and its two immediate progenitors, F. chiloensis and F. virginiana, are octoploids.
Davis, Thomas M., DiMeglio, Laura M., Staudt, Gunter, Yu, Hongrun   +3 more
core   +1 more source

Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAa receptor B3 subunit genes [PDF]

, 2004
Molecular genetic research has identified promising markers of alcohol dependence, including alleles of the D2 dopamine receptor (DRD2) and the GABAA receptor ￢3 subunit (GABRB3) genes.
Bandura, Bandura, Bau, Berman, Berridge, Blomqvist, Blum, Bruce R Lawford, Christiansen, Cohen, Comings, Connor, Connor, David, Davies, Depue, DiChiara, DiChiara, DiChiara, DiChiara, Dimitrov, Duan, Dudek, Ernest P Noble, Feeney, Gelernter, Gerald F.X Feeney, Goldman, Grandy, Greenfield, Gurling, Hitzemann, Hollerman, Ikemoto, Jönsson, Kidd, Knight, Laruelle, Lawford, Lawford, Lawford, Lawford, Long, Luddens, Madrid, Maldonado, McCarthy, McCarthy, Miller, Monti, Mutirangura, Neiswanger, Noble, Noble, Noble, Noble, Noble, Noble, Noble, Noble, Noone, Ott, Pato, Persico, Pohjalainen, Robinson, Ross McD Young, Schultz, Schultz, Selzer, Silvestri, Spitz, Terry Ritchie, Thanos, Thompson, Uhl, Vernon, Vik, Volkow, Volkow, Wells-Parker, Williams, Wilson, Wise, Young, Young, Young, Young   +87 more
core   +2 more sources