Results 191 to 200 of about 870,271 (337)

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

open access: yesAdvanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen   +7 more
wiley   +1 more source

A Complete Picture of the <i>CYP2D6</i> Heterogeneity in Northeastern Italian Genetic Isolates. [PDF]

open access: yesInt J Mol Sci
Tesolin P   +7 more
europepmc   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

open access: yesAdvanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen   +9 more
wiley   +1 more source

The association of class II HLA alleles with tuberculosis-associated immune reconstitution inflammatory syndrome. [PDF]

open access: yesPLoS Pathog
Choshi P   +10 more
europepmc   +1 more source

A Natural Major Module Confers the Trade‐Off between Phenotypic Mean and Plasticity of Grain Chalkiness in Rice

open access: yesAdvanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling the general trade‐off between phenotypic mean and plasticity of grain chalkiness in rice and identifies two major external drivers (high temperature and wide grain) and a natural major module (GCP6‐MPC5) that control this trade‐off.
Juncheng Zhang   +10 more
wiley   +1 more source

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