Results 221 to 230 of about 891,020 (314)

First Identification of <i>BoLA-DRB3</i> Alleles Associated with Differential Susceptibility to Bovine Leukemia Virus Infection and Proviral Load in Chinese Holstein Cattle. [PDF]

Pathogens
Wang J, Matsuura R, Watanuki S, Bao A, Fukushi N, Matsumoto Y, Dong L, Guo G, Yao C, Wang C, Wei F, Liu J, Wang X, Tian F, Wang J, Aida Y.   +15 more
europepmc   +1 more source

Massive parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity [PDF]

, 2019
Chase C. Suiter, Takaya Moriyama, Kenneth A. Matreyek, Wentao Yang, Emma Rose Scaletti, Rina Nishii, Wenjian Yang, Keito Hoshitsuki, Minu Singh, Amita Trehan, Christopher R. Parish, Colton Smith, Deepa Bhojwani, Liz Y. P. Yuen, Chi Kong Li, Chak-Ho Li, Yung‐Li Yang, G Walker, James Goodhand, Nicholas A. Kennedy, Federico Antillón‐Klussmann, Smita Bhatia, Mary V. Relling, Motohiro Kato, Hiroki Hori, Prateek Bhatia, Tariq Ahmad, Allen E. J. Yoeh, Pål Stenmark, Douglas M. Fowler, Jun J. Yang   +30 more
openalex   +1 more source

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

HLA-Knockout: Enabling Allele-Specific Knockout of HLA Class I Genes for Immunogenic Engineering. [PDF]

HLA
Mattivi C, Wang S, Ji L, Xiao Q, Cao J.
europepmc   +1 more source

Genome Wide Interaction Studies Identify Sex-Specific Risk Alleles for Nonsyndromic Orofacial Clefts [PDF]

, 2018
Jenna C. Carlson, Nichole Nidey, Azeez Butali, Carmen J. Buxó, Kaare Christensen, Frederic Deleyiannis, Jacqueline T. Hecht, L. Leigh Field, Lina Moreno‐Uribe, Iêda M. Orioli, Fernando A. Poletta, Carmencita D. Padilla, Alexandre R. Vieira, Seth M. Weinberg, George L. Wehby, Eleanor Feingold, Jeffrey C. Murray, Mary L. Marazita, Elizabeth J. Leslie   +18 more
openalex   +1 more source

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

Advanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang, Wanyou Feng, Yanyan Yang, Yu Pan, Chaoxia Zou, Leyi Wang, Sanbao Zhang, Yimin Zhao, Yongmei Wu, Jinling Wang, Jianwei Zou, Kehe Cen, Yongwang Zhang, Han Huang, Yurong Xu, Li Zhong, Hailong Gong, Juanru Cheng, Jingyuan Liang, Zihua Zheng, Qinyang Jiang, Jingwei Wei, Hui Li, Minhui Liang, Deshun Shi, Sufang Yang, Yanfei Deng, Yingming Wei   +27 more
wiley   +1 more source

Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates. [PDF]

Immunogenetics
Aartse A, Bakx JGJ, Mortier D, Hofman S, Mooij P, Claireaux M, Eggink D, Bogers WM, Remarque EJ, Corcoran MM, Karlsson Hedestam GB, Bontrop RE, van Gils MJ, Koopman G.   +13 more
europepmc   +1 more source

Structural Variation and 3D Genome‐Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication

Advanced Science, EarlyView.
These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao, Shangkun Jin, Haojie Jiang, Tianyu Pan, Zesheng Rui, Xiaowen Shi, Ting Zhao, Zhanfeng Si, Xueying Guan, Yan Hu, Tianzhen Zhang, Lei Fang   +11 more
wiley   +1 more source

Integrating Genomic and Climate Data to Design Representative Seed Production Areas: A Pragmatic Workflow for Climate-Adjusted Provenancing. [PDF]

Ecol Evol
Dimon RJ, Bragg J, Fahey P, van der Merwe M, Wilson PD, Henry R, Rossetto M.   +6 more
europepmc   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source