Results 251 to 260 of about 881,725 (335)

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans. [PDF]

PLoS Genet
Comerford M, Vespasiani DM, Shukla N, Cook LE, Yermakovich D, Dannemann M, Leavesley M, Kinipi C, Ricaut FX, Brucato N, Cox MP, Gallego Romero I.   +11 more
europepmc   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Preliminary results of a protein electrophoretic analysis of genetic variation, population structure and gene flow in the Nassau grouper, Epinephelus striatus [PDF]

, 2005
Hateley, J.G.
core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

The Bigger, the Better: Genetic and Phenotypic Analysis of Fruit Size in Sweet (<i>Prunus avium</i> L.) and Sour Cherry (<i>Prunus cerasus</i> L.) Germplasm. [PDF]

Plants (Basel)
Szilágyi S, Desiderio F, Marton B, Mohay P, Therese Navarro A, Békefi Z.   +5 more
europepmc   +1 more source

ELECTROMORPHS OR ALLELES? [PDF]

Genetics, 1977
openaire   +2 more sources

Allele Specificity of Naturally Acquired Antibody Responses against Plasmodium falciparum Apical Membrane Antigen 1

, 2004
Alfred Cortés, Mata Mellombo, Rosella Masciantonio, Vincent J. Murphy, John C. Reeder, Robin F. Anders   +5 more
openalex   +2 more sources

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, EarlyView.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source

A panoramic view of the expression and function of the Doublesex/DMRT gene family in <i>C. elegans</i>. [PDF]

Sci Adv
Wang 王琛 C, Salzberg Y, Oren-Suissa M, Hobert O.   +3 more
europepmc   +1 more source