Results 261 to 270 of about 881,725 (335)

HIV-1 Disease-Influencing Effects Associated with ZNRD1, HCP5 and HLA-C Alleles Are Attributable Mainly to Either HLA-A10 or HLA-B*57 Alleles

, 2008
Gabriel Catano, Hemant Kulkarni, Weijing He, Vincent C. Marconi, Brian K. Agan, Michael L. Landrum, Stephanie A. Anderson, Judith Delmar, Vanessa Telles, Li Song, John Castiblanco, Robert A. Clark, Matthew J. Dolan, Sunil K. Ahuja   +13 more
openalex   +2 more sources

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Genomic insights into the spread and evolution of insecticide resistance variants in Anopheles gambiae s.l. from Burkina Faso. [PDF]

Sci Rep
Kientega M, Kaboré H, Sawadogo G, Hui TJ, Traoré N, Millogo AA, Maiga H, Miles A, Clarkson CS, Diabaté A.   +9 more
europepmc   +1 more source

Phase I clinical study of a peptide vaccination for hepatitis C virus‐infected patients with different human leukocyte antigen‐class I‐A alleles

, 2009
Shigeru Yutani, Nobukazu Komatsu, Shigeki Shichijo, Kazumi Yoshida, Hiroko Takedatsu, Minoru Itou, Ryoko Kuromatu, Tatsuya Ide, Masatoshi Tanaka, Michio Sata, Akira Yamada, Kyogo Itoh   +11 more
openalex   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Panton-Valentine Leukocidin-Encoding Methicillin-Resistant Staphylococcus aureus, the Netherlands, 2023-2024¹. [PDF]

Emerg Infect Dis
van Schelven P, Nijhuis R, Jamin C, Goemans S, Hintaran P, van der Jagt-Zwetsloot M, Smilde A, Ter Horst A, de Graaf M, Notermans DW, Russcher A, Raven S.   +11 more
europepmc   +1 more source

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

Using machine learning to predict and analyze complex trait diseases: Lessons from a simple abstract model. [PDF]

PLoS One
Maimon E, Bondi O, Moult J, Unger R.
europepmc   +1 more source

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

Perivitelline Membrane-Bound Sperm as a Source of Paternal Genomic DNA to Inform Breeding Male Marine Turtle Genetics and Demographics. [PDF]

Ecol Evol
Shamblin BM, Sanchez CL, Perry SM, Ceriani SA.   +3 more
europepmc   +1 more source