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Structural Relatedness of Plant Food Allergens With Specific Reference to Cross-Reactive Allergens: An in Silico Analysis

open access: yesJournal of Allergy and Clinical Immunology, 2005
The body of sequence and structural information on allergens and the sequence analysis of whole plant genomes are facilitating the application of bioinformatic approaches to identifying and defining plant allergens.
Sam Griffiths-Jones   +2 more
exaly   +2 more sources
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Allergens

Immunology and Allergy Clinics of North America, 2005
Exposure to allergens is a trigger for symptoms in sensitized individuals with asthma. This is especially true for allergens primarily found indoors but can be true for outdoor allergens with sufficiently high exposure. The role of allergens in attacks can be subtle in that they provide the underlying inflammation necessary for other nonspecific agents
Elizabeth A, Erwin   +1 more
openaire   +2 more sources

Allergen motifs and the prediction of allergenicity

Immunology Letters, 2007
We have recently shown that the majority of allergens can be represented by allergen motifs. This observation prompted us to experimentally investigate the synthesized peptides corresponding to the in silico motifs with regard to potential IgE binding and cross-reactions with allergens.
Marti, Pamela   +9 more
openaire   +4 more sources

Allergen nomenclature

Journal of Allergy and Clinical Immunology, 1995
This is a revision of the allergen nomenclature system which was proposed in 1986. The nomenclature is for allergens which induce IgE-mediated allergy in humans. A table of allergens with known partial or complete sequences as of December 1993 is given.
T P, King   +5 more
openaire   +2 more sources

Recombinant allergens/ allergen standardization

Current Allergy and Asthma Reports, 2001
Recombinant allergens are genetically engineered isoforms representing allergen molecules from allergen extracts. Immunologic responses of allergic patients toward allergen extracts define the major allergens. For the average allergic patient, the diagnostic sensitivity and treatment efficacy correlate with the concentration of major allergen ...
H, Løwenstein, J N, Larsen
openaire   +2 more sources

Allergy, allergens and allergen standardization

Medical Journal of Australia, 1984
Immediate, type 1 allergic reactions occur following interaction between allergen, immunoglobulin E (IgE), and the mast cell or basophil. Allergen-induced activation of these cells leads to the release of a number of mediators that are responsible for the symptoms observed during an allergic reaction.
B A, Baldo, E R, Tovey
openaire   +2 more sources

Allergens

Clinical Reviews in Allergy & Immunology, 2001
What makes an antigen an allergen? This question has been at the core of much research regarding the basic mechanisms of allergy as well as the development of diagnostic and therapeutic allergen products. Great strides have been made since Kjell Aas asked this question in his classic review in Allergy (1), but we appear no closer to the answer.
openaire   +3 more sources

Allergens

Primary Care: Clinics in Office Practice, 1987
The environment contains a huge array of allergens, primarily proteins or glycoproteins, to which the atopic individual may become sensitized. In situations of high exposure and highly reactive substances, even nonatopic individuals may develop allergic antibodies.
openaire   +2 more sources

Allergen Microarrays

2005
Allergy affects more than 25% of Western populations (1) and is estimated to be the sixth leading cause of chronic disease in the United States and Western Europe. The complexity of the condition is such that hundreds of common allergens have been described, and in order to maximize diagnostic efficiency there is an urgent clinical requirement for ...
Bacarese Hamilton T.   +3 more
openaire   +5 more sources

Updates on Databases of Allergens and Allergen-Epitopes

2023
The increasing prevalence of allergic diseases is of great public health concern. Environmental and food allergens are the major triggers of allergic diseases via respiratory or gastrointestinal routes, respectively. A major setback in the clinical management of allergies is the unavailability of purified allergens required for diagnostic purposes ...
Rajat Kanti, Sarkar   +3 more
openaire   +2 more sources

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