Results 1 to 10 of about 143,532 (215)

Allergic Endotypes and Phenotypes of Asthma [PDF]

Journal of Allergy and Clinical Immunology: in Practice, 2020
Allergic asthma is defined as asthma associated with sensitization to aeroallergens, which leads to asthma symptoms and airway inflammation. Allergic asthma is the most common asthma phenotype. The onset of allergic asthma is most often in childhood and is usually accompanied by other comorbidities including atopic dermatitis and allergic rhinitis.
Nicole Akar-Ghibril, Thomas B Casalé, Adnan Custovic   +2 more
exaly   +4 more sources

Asthma, allergic rhinitis and eczema among parents of preschool children in relation to climate, and dampness and mold in dwellings in China

Environment International, 2019
The main aim was to study associations between asthma, allergic rhinitis and eczema among adults across China and dampness and mold at home. Young adults (N = 40,279) in eight cities in China answered a questionnaire in 2010–2012 (response rate 75.0 ...
Juan Wang, Zhuohui Zhao, Yinping Zhang   +2 more
exaly   +3 more sources

The levels and impacting factors of serum amyloid A in the acute exacerbation of allergic asthma [PDF]

Yixue xinzhi zazhi, 2022
Objective To analyze the expression levels of serum amyloid A (SAA) in patients with allergic and non-allergic asthma, and explore the correlation between SAA and acute exacerbation severity and identify biomarkers of allergic asthma.Methods Asthmatic ...
Yan-Wen CUI, Li-Hui WANG, Chun-Xian DU, Ya-Dong GAO   +3 more
doaj   +1 more source

A systems immunology approach to investigate cytokine responses to viruses and bacteria and their association with disease

Scientific Reports, 2022
Patterns of human immune responses to viruses and bacteria and how this impacts risk of infections or onset/exacerbation of chronic respiratory diseases are poorly understood.
Lijing Lin, John A. Curtin, Eteri Regis, Aurica Hirsman, Rebecca Howard, Mauro Tutino, Michael R. Edwards, Mattia Prosperi, Angela Simpson, Magnus Rattray, Adnan Custovic, Sebastian L. Johnston   +11 more
doaj   +1 more source

Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium

Frontiers in Genetics, 2020
BackgroundAsthma is a chronic airway disease driven by complex genetic–environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood.MethodsWe piloted genome-wide profiling of the ...
Peter McErlean, Peter McErlean, Audrey Kelly, Audrey Kelly, Jaideep Dhariwal, Jaideep Dhariwal, Max Kirtland, Max Kirtland, Julie Watson, Julie Watson, Ismael Ranz, Ismael Ranz, Janet Smith, Alka Saxena, David J. Cousins, David J. Cousins, Antoon Van Oosterhout, Roberto Solari, Roberto Solari, Michael R. Edwards, Michael R. Edwards, Sebastian L. Johnston, Sebastian L. Johnston, Paul Lavender, Paul Lavender   +24 more
doaj   +1 more source

Age at asthma diagnosis and onset of symptoms among adults with allergic and non-allergic asthma

European Clinical Respiratory Journal, 2023
Background Childhood-onset allergic asthma is the best-known phenotype of asthma. Adult-onset asthma, also an important entity, is instead often shown to be more non-allergic.
Johanna Pakkasela, Petri Salmela, Pekka Juntunen, Jussi Karjalainen, Lauri Lehtimäki   +4 more
doaj   +1 more source

Classification of non-acute bronchial asthma according to allergy and eosinophil characteristics: a retrospective study

Allergy, Asthma & Clinical Immunology, 2021
Background Investigating the endotypes of the different asthma phenotypes would help disease monitoring, prognosis determination, and improving asthma management standardization.
Yi Jiang, Ruoli An, Li Cheng, Qianru Yue, Hanwei Zhang, Yali Zhang, Xiaomei Kong, Hongxia Ma, Fang Chen, Yufeng Guo   +9 more
doaj   +1 more source

Involvement of CCL18 in allergic asthma [PDF]

The Journal of Immunology, 2006
Abstract Allergic asthma is associated with a pulmonary recruitment of Th type 2 cells, basophils, and eosinophils, mainly linked to chemokine production. CCL18 is a chemokine preferentially expressed in the lung, secreted by APCs, induced by Th2-type cytokines, and only present in humans.
De Nadai, Patricia, Charbonnier, Anne-Sophie, Chenivesse, Cécile, Sénéchal, Stéphanie, Fournier, Clément, Gilet, Jules, Vorng, Han, Chang, Ying, Gosset, Philippe, Wallaert, Benoît, Tonnel, André-Bernard, Lassalle, Philippe, Tsicopoulos, Anne   +12 more
openaire   +5 more sources

Eosinophilic Inflammation in Allergic Asthma [PDF]

Frontiers in Pharmacology, 2013
Eosinophils are circulating granulocytes involved in pathogenesis of asthma. A cascade of processes directed by Th2 cytokine producing T-cells influence the recruitment of eosinophils into the lungs. Furthermore, multiple elements including interleukin (IL)-5, IL-13, chemoattractants such as eotaxin, Clara cells, and CC chemokine receptor (CCR)3 are ...
Possa, Samantha S., Leick, Edna A., Prado, Carla M., Martins, Mílton A., Tibério, Iolanda F. L. C.   +4 more
openaire   +3 more sources

Incidence and timing of offspring asthma, wheeze, allergic rhinitis, atopic dermatitis, and food allergy and association with maternal history of asthma and allergic rhinitis

World Allergy Organization Journal, 2021
Background: Studying the developmental precursors of allergy may help explain the mechanisms (or etiology) of allergic disease. We studied childhood respiratory and allergic diseases in a pre-birth cohort from the United States.
Carina Venter, Michaela P. Palumbo, Katherine A. Sauder, Deborah H. Glueck, Andrew H. Liu, Ivana V. Yang, Miriam Ben-Abdallah, David M. Fleischer, Dana Dabelea   +8 more
doaj   +1 more source