Results 51 to 60 of about 5,211,261 (208)

Profiling of H3K27Ac Reveals the Influence of Asthma on the Epigenome of the Airway Epithelium

Frontiers in Genetics, 2020
BackgroundAsthma is a chronic airway disease driven by complex genetic–environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood.MethodsWe piloted genome-wide profiling of the ...
Peter McErlean, Peter McErlean, Audrey Kelly, Audrey Kelly, Jaideep Dhariwal, Jaideep Dhariwal, Max Kirtland, Max Kirtland, Julie Watson, Julie Watson, Ismael Ranz, Ismael Ranz, Janet Smith, Alka Saxena, David J. Cousins, David J. Cousins, Antoon Van Oosterhout, Roberto Solari, Roberto Solari, Michael R. Edwards, Michael R. Edwards, Sebastian L. Johnston, Sebastian L. Johnston, Paul Lavender, Paul Lavender   +24 more
doaj   +1 more source

The strategies that peanut and nut-allergic consumers employ to remain safe when travelling abroad [PDF]

, 2012
Copyright @ 2012 Barnett et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use ...
Lucas Jane S, Botting, N, Lucas, Jane S., Botting, Neil, Julie Barnett, Barnett, J, M Hazel Gowland, Barnett, Julie, Gowland, MH, Neil Botting, Gowland, M. Hazel, Botting Neil, Jane S Lucas, Barnett Julie, Lucas, JS, Gowland M   +15 more
core   +1 more source

Automated chart review utilizing natural language processing algorithm for asthma predictive index

BMC Pulmonary Medicine, 2018
Background Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and validate a natural language processing (
Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A. Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A. Castro-Rodriguez, Gretchen A. Voge, Hongfang Liu, Young J. Juhn   +11 more
doaj   +1 more source

Short-Chain Fatty Acids Calibrate RARα Activity Regulating Food Sensitization

Frontiers in Immunology, 2021
Gut-microbiota dysbiosis links to allergic diseases. The mechanism of the exacerbation of food allergy caused by gut-microbiota dysbiosis remains unknown. Regulation of retinoic acid receptor alpha (RARα) signaling is critical for gut immune homeostasis.
Xiefang Yuan, Hongmei Tang, Renlan Wu, Xingjie Li, Xingjie Li, Hongyu Jiang, Hongyu Jiang, Zhigang Liu, Zongde Zhang, Zongde Zhang   +9 more
doaj   +1 more source

FSP1 is a predictive biomarker of osteosarcoma cells’ susceptibility to ferroptotic cell death and a potential therapeutic target

Cell Death Discovery
Human osteosarcoma (OS) is a relatively rare malignancy preferentially affecting long body bones which prognosis is often poor also due to the lack of effective therapies. Clinical management of this cancer basically relies on surgical removal of primary
Elzbieta Panczyszyn, Valentina Saverio, Romina Monzani, Mara Gagliardi, Jelena Petrovic, Jasmina Stojkovska, Licio Collavin, Marco Corazzari   +7 more
doaj   +1 more source

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease [PDF]

, 2013
Background: Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD).
Groneberg, David A., David A Groneberg, Fischer, Axel, Frank R Scholz, Springer, Jochen, Jochen Springer, Groneberg, Jan David Alexander, Christian Peiser, Scholz, Frank R., Axel Fischer, Peiser, Christian, Q Dinh, Quarcoo, David, David Quarcoo, Dinh, Q. Thai   +14 more
core   +1 more source

AKRs confer oligodendrocytes resistance to differentiation-stimulated ferroptosis

Redox Biology
Ferroptosis is a recently characterized form of cell death that has gained attention for its roles in both pathological and physiological contexts. The existence of multiple anti-ferroptotic pathways in both neoplastic and healthy cells, along with the ...
Valentina Saverio, Emanuele Ferrario, Romina Monzani, Mara Gagliardi, Francesco Favero, Davide Corà, Claudio Santoro, Marco Corazzari   +7 more
doaj   +1 more source

T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects [PDF]

, 2009
Lipid transfer proteins (LTPs), particularly peach Pru p 3, are the most relevant plant food allergens in the South of Europe, and, therefore, their allergic properties have been extensively studied.
Tordesillas Villuendas, Leticia, Sánchez-Monge Laguna de Rins, Rosa, Gonzalez-Muñoz, Miguel, Salcedo Duran, Gabriel, Pacios, Luis F., Compes, Esther, Díaz Perales, Araceli, Belen Garcia-Carrasco, Esther Compés, Cuesta-Herranz, Javier, Gabriel Salcedo, Rosa Sanchez-Monge, Miguel Gonzalez-Muñoz, Javier Cuesta-Herranz, Leticia Tordesillas, Garcia-Carrasco, Belen, Luis F. Pacios, Araceli Diaz-Perales   +17 more
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TLR4+group 2 innate lymphoid cells contribute to persistent type 2 immunity in airway diseases

Nature Communications
Group 2 innate lymphoid cells (ILC2s) directly contribute to local inflammation in type 2 inflammatory airway diseases. Here, we identify ILC2 subsets by single cell RNA sequencing in chronic rhinosinusitis with nasal polyps (CRSwNP) and in a memory ...
Yan Li, Zaichuan Wang, Su Duan, Xue Wang, Yuling Zhang, Claus Bachert, Nan Zhang, Wei Wang, Sun Ying, Feng Lan, Chengshuo Wang, Luo Zhang   +11 more
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Human cytomegalovirus infection triggers a paracrine senescence loop in renal epithelial cells

Communications Biology
Human cytomegalovirus (HCMV) is an opportunistic pathogen causing severe diseases in immunosuppressed individuals. To replicate its double-stranded DNA genome, HCMV induces profound changes in cellular homeostasis that may resemble senescence.
Stefano Raviola, Gloria Griffante, Andrea Iannucci, Shikha Chandel, Irene Lo Cigno, Davide Lacarbonara, Valeria Caneparo, Selina Pasquero, Francesco Favero, Davide Corà, Elena Trisolini, Renzo Boldorini, Vincenzo Cantaluppi, Santo Landolfo, Marisa Gariglio, Marco De Andrea   +15 more
doaj   +1 more source