Results 1 to 10 of about 227,629 (120)

Immunophenotypes of anti-SARS-CoV-2 responses associated with fatal COVID-19

ERJ Open Research, 2022
Background The relationship between anti-SARS-CoV-2 humoral immune response, pathogenic inflammation, lymphocytes and fatal COVID-19 is poorly understood.
Julij Šelb, Barbara Bitežnik, Urška Bidovec Stojković, Boštjan Rituper, Katarina Osolnik, Peter Kopač, Petra Svetina, Kristina Cerk Porenta, Franc Šifrer, Petra Lorber, Darinka Trinkaus Leiler, Tomaž Hafner, Tina Jerič, Robert Marčun, Nika Lalek, Nina Frelih, Mojca Bizjak, Rok Lombar, Vesna Nikolić, Katja Adamič, Katja Mohorčič, Sanja Grm Zupan, Irena Šarc, Jerneja Debeljak, Ana Koren, Ajda Demšar Luzar, Matija Rijavec, Izidor Kern, Matjaž Fležar, Aleš Rozman, Peter Korošec   +30 more
doaj   +1 more source

T2-high Asthma, Classified by Sputum mRNA Expression of IL4, IL5, and IL13, is Characterized by Eosinophilia and Severe Phenotype

Life, 2021
Asthma is a common chronic disease, with different underlying inflammatory mechanisms. Identification of asthma endotypes, which reflect a variable response to different treatments, is important for more precise asthma management.
Matija Rijavec, Tomaž Krumpestar, Sabina Škrgat, Izidor Kern, Peter Korošec   +4 more
doaj   +1 more source

Ribosomal Dysfunction Is a Common Pathomechanism in Different Forms of Trichothiodystrophy

Cells, 2023
Mutations in a broad variety of genes can provoke the severe childhood disorder trichothiodystrophy (TTD) that is classified as a DNA repair disease or a transcription syndrome of RNA polymerase II.
Gaojie Zhu, Fatima Khalid, Danhui Zhang, Zhouli Cao, Pallab Maity, Hans A. Kestler, Donata Orioli, Karin Scharffetter-Kochanek, Sebastian Iben   +8 more
doaj   +1 more source

Hymenoptera Venom Immunotherapy: Immune Mechanisms of Induced Protection and Tolerance

Cells, 2021
Hymenoptera venom allergy is one of the most severe allergic diseases, with a considerable prevalence of anaphylactic reaction, making it potentially lethal.
Ajda Demšar Luzar, Peter Korošec, Mitja Košnik, Mihaela Zidarn, Matija Rijavec   +4 more
doaj   +1 more source

RUNX3 mediates keloid fibroblast proliferation through deacetylation of EZH2 by SIRT1

BMC Molecular and Cell Biology, 2022
Background Keloid is a benign proliferative fibrous disease featured by excessive fibroblast proliferation after skin injury. However, the mechanism of abnormal cell proliferation is still unclear.
Hanye Liu, Guanghai Yan, Li Li, Dandan Wang, Yu Wang, Shan Jin, Zhehu Jin, Liangchang Li, Lianhua Zhu   +8 more
doaj   +1 more source

Current and emerging biologic therapies targeting eosinophilic disorders

World Allergy Organization Journal, 2022
Eosinophilic disorders include a wide array of conditions in which eosinophils play a primary pathophysiologic role. While historically treated with corticosteroids and immunosuppressants, knowledge of eosinophil biology has led to the development of ...
Mitchell M. Pitlick, MD, James T. Li, MD, PhD, Thanai Pongdee, MD   +2 more
doaj   +1 more source

Gene expression profiles and bioinformatics analysis in lung samples from ovalbumin-induced asthmatic mice

BMC Pulmonary Medicine, 2023
Background Asthma is characterized by chronic inflammation and airway remodeling. However, limited study is conducted on the gene expression profiles of ovalbumin (OVA) induced asthma in mice.
Yilan Song, Jingzhi Jiang, Qiaoyun Bai, Siqi Liu, Yalin Zhang, Chang Xu, Hongmei Piao, Liangchang Li, Guanghai Yan   +8 more
doaj   +1 more source

Risks and safety of biologics: A practical guide for allergists

World Allergy Organization Journal, 2023
Biologic agents are a rapidly expanding class of medications, and several options are now available for the management of allergic and immunologic disorders.
Andrea N. Sitek, MD, James T. Li, MD, PhD, Thanai Pongdee, MD   +2 more
doaj   +1 more source

Utility of Telomerase Gene Mutation Testing in Patients with Idiopathic Pulmonary Fibrosis in Routine Practice

Cells, 2022
Recent studies have suggested that causative variants in telomerase complex genes (TCGs) are present in around 10% of individuals with idiopathic pulmonary fibrosis (IPF) regardless of family history of the disease.
Julij Šelb, Katarina Osolnik, Izidor Kern, Peter Korošec, Matija Rijavec   +4 more
doaj   +1 more source

Superoxide anion radicals induce IGF‐1 resistance through concomitant activation of PTP1B and PTEN

EMBO Molecular Medicine, 2014
The evolutionarily conserved IGF‐1 signalling pathway is associated with longevity, metabolism, tissue homeostasis, and cancer progression. Its regulation relies on the delicate balance between activating kinases and suppressing phosphatases and is still
Karmveer Singh, Pallab Maity, Linda Krug, Patrick Meyer, Nicolai Treiber, Tanja Lucas, Abhijit Basu, Stefan Kochanek, Meinhard Wlaschek, Hartmut Geiger, Karin Scharffetter‐Kochanek   +10 more
doaj   +1 more source