Causal effects of antibody-mediated immune responses on allergic diseases: A bidirectional Mendelian randomization study. [PDF]
Medicine (Baltimore)Leng L, Xu T, Tang Q, Li Y, Li X.
europepmc +1 more source
Allergic rhinitis in college students at Dongguan: a cross-sectional survey on disease burden, knowledge, and self-management [PDF]
Xin Peng +5 more
openalex +1 more source
Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis
Advanced Science, EarlyView.Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao +10 more
wiley +1 more source
The Microecological-Immune Axis in Pediatric Allergic Diseases: Imbalance Mechanisms and Regulatory Interventions. [PDF]
NutrientsJiang Z +6 more
europepmc +1 more source
Advanced Science, EarlyView.In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo +14 more
wiley +1 more source
Effectiveness of the antihistamine and anti-PAF effects of rupatadine in allergic diseases: off-label use in a case series study. [PDF]
Drugs ContextAguiar R +4 more
europepmc +1 more source
Advanced Science, EarlyView.This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang +12 more
wiley +1 more source
Association between allergic diseases and influenza or pneumonia incidence among children in the United States: A nationally representative study. [PDF]
Medicine (Baltimore)Zhang J, Yang D, Lu J, Wang H, Zhang J.
europepmc +1 more source
A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4
Advanced Science, EarlyView.This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He +11 more
wiley +1 more source