Results 91 to 100 of about 217,585 (300)

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Allergic sensitization related to age and clinical presentation [PDF]

, 2016
Cilj: Odrediti profil alergijske senzitizacije i okidače alergijskih simptoma prema dobi djeteta i tipu alergijske bolesti. Ispitanici i metode: Restrospektivno su analizirani rezultati kožnih ubodnih testova na inhalatorne i nutritivne alergene u ...
Monika Mačkić, Kvenić, Barbara, Bojana Đokić, Tea Crnogaj, Banac, Srđan, Milana Đorđevski, Đorđevski, Milana, Mačkić, Monika, Barbara Kvenić, Crnogaj, Tea, Đokić, Bojana, Srđan Banac   +11 more
core   +1 more source

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA)

Arthritis &Rheumatology, Accepted Article.
Objectives The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing (RNAseq) in vastus lateralis muscle, resulting in 523 participants (56% female ...
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

Distinct IgE sensitization profiles in chronic urticaria: a comparative study with classic allergic diseases

Frontiers in Immunology
IntroductionChronic urticaria (CU) is not traditionally classified as an allergic disease, but emerging evidence suggests a link to atopy. The quintessential marker of atopy is IgE sensitization, there is scarce information on the IgE sensitization ...
Xianjie Yang, Shifei Li, Anqi Chen, Huan Wang, Sisi Deng, Bing Ni, Zhiqiang Song, Qiquan Chen, Qiquan Chen   +8 more
doaj   +1 more source

Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus [PDF]

, 2008
High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial mediators of autoimmune diseases.
Wichmann, H. -Erich, Ursula Krämer, Liang Liming, Markus Ollert, Stephan Weidinger, Mempel, Martin, Bauer, Carl Peter, Baurecht Hansjörg, Prokisch Holger, Mehta Divya, von Berg, A., von Mutius, Erika, Bauer Carl Peter, Gohlke, H., Cookson, W., Depner, Martin, Wagenpfeil, S., Wichmann, H.-E., Illig, T., Michael Kabesch, Mempel, M., Novak, N., Mehta, D., Illig Thomas, Liang, L., Kabesch, Michael, von Berg Andrea, Moffatt Miriam, Prokisch, H., Heinrich Joachim, Herbarth, Olf, Gohlke Henning, Bieber, Thomas, Olf Herbarth, Martin Depner, Stefan Wagenpfeil, Heinrich, Joachim, H-Erich Wichmann, Erika von Mutius, Heinrich, J., Gieger, Christian, Heidrun Behrendt, Ollert Markus, Thomas Bieber, Meitinger, T., Divya Mehta, Ring, Johannes, Rodriguez Elke, Herbarth Olf, Miriam Moffatt, Natalija Novak, von Mutius Erika, Cookson William, Mehta, Divya, Behrendt Heidrun, Klopp, Norman, Ring Johannes, Bieber Thomas, Cookson, William, Sibylle Koletzko, Meitinger Thomas, Wichmann, Heinz-Erich, Mempel Martin, Hansjörg Baurecht, William Cookson, Kraemer, Ursula, Gieger, C., Gohlke, Henning, Christian Gieger, Baurecht, H., Depner Martin, Kabesch Michael, Weidinger, S., Bieber, T., Herbarth, O., Novak, Natalija, Berdel Dietrich, Moffatt, M., Berdel, D., von Mutius, E., Koletzko, Sibylle, Klopp, N., Krämer Ursula, Gieger Christian, Liang, Liming, Bauer, C.P., Johannes Ring, Berdel, Dietrich, Wagenpfeil, Stefan, Mutius, Erika von, Koletzko Sibylle, Koletzko, S., Rodriguez, E., Krämer, U., Ollert, Markus, Ollert, M., Rodriguez, Elke, Wichmann H.-Erich, Kabesch, M., Behrendt, H., Prokisch, Holger, Moffatt, Miriam, Henning Gohlke, Carl Peter Bauer, Illig, Thomas, Meitinger, Thomas, Liming Liang, Joachim Heinrich, Andrea von Berg, Thomas Illig, Novak Natalija, von Berg, Andrea, Weidinger, Stephan, Weidinger Stephan, Klopp Norman, Baurecht, Hansjoerg, Behrendt, Heidrun, Thomas Meitinger, Depner, M., Berg, Andrea von, Dietrich Berdel, Ring, J., Wagenpfeil Stefan, Elke Rodriguez, Norman Klopp, Martin Mempel, Holger Prokisch, Weidinger, S;Gieger, C;Rodriguez, E;Baurecht, H;Mempel, M;Klopp, N;Gohlke, H;Wagenpfeil, S;Ollert, M;Ring, J;Behrendt, H;Heinrich, J;Novak, N;Bieber, T;Kramer, U;Berdel, D;von Berg, A;Bauer, CP;Herbarth, O;Koletzko, S;Prokisch, H;Mehta, D;Meitinger, T;Depner, M;von Mutius, E;Liang, L;Moffatt, M;Cookson, W;Kabesch, M;Wichmann, HE;Illig, T   +127 more
core   +1 more source

Dissecting the dissection laboratory: Elements for designing a human anatomy laboratory

Anatomical Sciences Education, EarlyView.
Abstract The human anatomy dissection laboratory is a critical component of anatomical and medical education. Development, maintenance, and stocking of these laboratory spaces have unique demands, with all of the challenges in running a laboratory with Biosafety Laboratory Level 2 (BSL‐2) classification, housing a large volume of tissues saturated with
Rhiannon E. Robinson, Abbey Breckling, Danielle N. Edwards, Nicole Geske, Burhan Gharaibeh, Bobbie J. Leeper, Molly Ostwald, Mary Schilling, Bridgett Severt, Kelsey Stevens, J. P. Swigart, Jonathan J. Wisco, Melissa Zolnierz, Jeremy J. Grachan   +13 more
wiley   +1 more source

Alarming Dendritic Cells for Allergic Sensitization

Allergology International, 2010
Allergic patients mount a Th2 response to common allergens, like house dust mite (HDM), pollens, molds and animal dander. Most inhaled antigens are immunologically inert, however if these antigens are accompanied by microbial or endogenous danger patterns (alarmins), they can be recognized by inflammatory cells.
Willart, Monique A.M., Hammad, Hamida
openaire   +2 more sources

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

HLA‐B*15:21 carrier status is a susceptibility factor of carbamazepine‐induced nonimmediate cutaneous adverse reactions in HLA‐B*15:02‐negative patients: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
After HLA‐B*15:02 screening, the residual risk of carbamazepine‐induced nonimmediate cutaneous adverse reactions is 0.059. Among these HLA‐B*15:02‐negative cases, HLA‐B*15:11 and HLA‐B*15:21 carrier status significantly increases the risk of carbamazepine‐induced nonimmediate cADR.
Warit Ruanglertboon, Chutima Seree‐aphinan, Antida Sangiemchoey, Khwanchanok Kaewpiboon, Taweesak Maneerot, Oradawan Plong‐on, Pornsiri Sangmanee, Punthipa Nichanon, Jariya Khayman, Jiraphan Manee, Areerat Hnoonual, Kanoot Jaruthamsophon   +11 more
wiley   +1 more source

Allergic Contact Sensitization to the Toluic Acids

Journal of Investigative Dermatology, 1973
Para-toluic acid (1:4 methylbenzoic acid) and ortho-toluic acid were found to be potent allergic sensitizers when applied to human skin. Cross-sensitivity was found between all three isomers, p-toluic, m-toluic, and o-toluic acids. It is suggested that this cross-sensitivity is explicable in terms of carrier protein specificity rather than by the ...
Emmett, Edward A., Suskind, Raymond R.
openaire   +2 more sources