Results 21 to 30 of about 8,866 (255)

Alligator Abundance and Hydrology (2003–2013): What Long-term Monitoring Can Tell Us about Everglades Restoration

EDIS, 2014
The American alligator is a powerful indicator for Everglades restoration. It responds clearly to environmental change and is easy and inexpensive to monitor.
Rebecca G. Harvey, Jeff Beauchamp, Robin Bijlani, Frank J. Mazzotti, Laura A. Brandt   +4 more
doaj   +5 more sources

RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties

mAbs
Despite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges.
Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz   +8 more
doaj   +1 more source

Alligator presence influences colony site selection of long-legged wading birds through large scale facilitative nest protector relationship

Scientific Reports, 2021
Positive ecological relationships, such as facilitation, are an important force in community organization. The effects of facilitative relationships can be strong enough to cause changes in the distributions of species and in many cases have evolved as a
Wray Gabel, Peter Frederick, Jabi Zabala
doaj   +1 more source

Morphometrics of the Spinal Cord and Surrounding Structures in Alligator mississippiensis

Biology, 2022
Understanding the fluid dynamics of the cerebrospinal fluid requires a quantitative description of the spaces in which it flows, including the spinal cord and surrounding meninges. The morphometrics of the spinal cord and surrounding tissues were studied
Skye Greer, Michael J. Cramberg, Bruce A. Young   +2 more
doaj   +1 more source

Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform

Drug Delivery
Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy.
Barnabas Nyesiga, Karin Hägerbrand, Laura Varas, Anette Gjörloff Wingren, Mats Ohlin, Peter Ellmark, Laura von Schantz   +6 more
doaj   +1 more source

Heterophil/Lymphocyte Alterations as a Measure of Stress in American Alligators in Relation to Anthropogenic Disturbance in a Louisiana Intermediate Marsh

Journal of Marine Science and Engineering, 2015
Numerous anthropogenic factors represent environmental threats to Gulf Coast wetland ecosystems and associated fauna. American alligators (Alligator mississippiensis) have been subject to long-term management and used as ecological and physiological ...
Christopher M. Murray, Justin L. Rheubert, Michael E. Easter, Mark Merchant, Brian I. Crother   +4 more
doaj   +1 more source

Formants provide honest acoustic cues to body size in American alligators

Scientific Reports, 2017
In many vertebrates, acoustic cues to body size are encoded in resonance frequencies of the vocal tract (“formants”), rather than in the rate of tissue vibration in the sound source (“pitch”).
Stephan A. Reber, Judith Janisch, Kevin Torregrosa, Jim Darlington, Kent A. Vliet, W. Tecumseh Fitch   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Sex-Biased miRNAs in the Gonads of Adult Chinese Alligator (Alligator sinensis) and Their Potential Roles in Sex Maintenance

Frontiers in Genetics, 2022
MicroRNA (miRNA) is a category of single-stranded non-coding small RNA (sRNA) that regulates gene expression by targeting mRNA. It plays a key role in the temperature-dependent sex determination of Chinese alligator (Alligator sinensis), a reptile whose ...
Meng-Yuan Hu, Jun Yu, Jian-Qing Lin, Jian-Qing Lin, Sheng-Guo Fang   +4 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source