Results 31 to 40 of about 8,866 (255)

Constitutive Innate Immunity and Systemic Responses to Infection of the American Alligator (Alligator mississippiensis)

Animals
Uninfected alligators (Alligator mississippiensis) exhibited high constitutive levels of hepatic gene expression related to immune function, whereas the highest-expressed hepatic genes of uninfected mice were related to metabolism.
Mark Merchant, Matthew Hebert, Anna C. Salvador, Jennifer Berken, Thomas Boverie, Mary E. White   +5 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Composites of Shellac and Silver Nanowires as Flexible, Biobased, and Corrosion‐Resistant Transparent Conductive Electrodes

Advanced Functional Materials, EarlyView.
Shellac, a centuries‐old natural resin, is reimagined as a green material for flexible electronics. When combined with silver nanowires, shellac films deliver transparency, conductivity, and stability against humidity. These results position shellac as a sustainable alternative to synthetic polymers for transparent conductors in next‐generation ...
Rahaf Nafez Hussein, Tiago Carneiro Gomes, Eliza Ng, Simon Rondeau‐Gagné, Tricia Breen Carmichael   +4 more
wiley   +1 more source

First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies

Journal for ImmunoTherapy of Cancer
Background ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell ...
Peter Ellmark, Jeffrey Yachnin, Ana Carneiro, Lena Schultz, Amanda Hahn, Sumeet Ambarkhane, Karin Enell Smith, Gustav J. Ullenhag   +7 more
doaj   +1 more source

Analysis of nutritional and odor components in muscle of Siam alligator (Crocodylus siamensis)

浙江大学学报. 农业与生命科学版, 2013
Crocodile is covered in treasure. Its leather has a high reputation in the world, and its armour contains a lot of bone collagen, protein, calcium, phosphorus and so on, and its gallbladder contains more than 20 kinds of bile acids and bilichols, which ...
QUE Tingting, XIE Yan, ZHENG Jiawen, HU Qinglan, HU Yaqin, LUO Zisheng   +5 more
doaj   +1 more source

Multicomponent Peptide‐MXene‐Hyaluronic Acid Hydrogel as a Conductive Scaffold for Enhanced Fibroblast Proliferation and Migration Under Electrical Stimulation

Advanced Healthcare Materials, EarlyView.
An electrically conductive FmocFF/MXene/hyaluronic acid hydrogel combines extracellular matrix‐like architecture, self‐healing behavior, oxidation‐resistant conductivity, and biochemical cues in a single scaffold. By enabling physiologically relevant electrical stimulation, the platform enhances fibroblast attachment, proliferation, and migration ...
Offir Loboda, Dana Cohen‐Gerassi, Dor Aaron Goldstein, Or Messer, Bar Favelukis, Ehud Gazit, Maxim Sokol, Lihi Adler‐Abramovich   +7 more
wiley   +1 more source

Size-dependent effects of the intestinal microbiota in juvenile Chinese alligators: implications for species protection

Frontiers in Zoology
Increasing the quality of offspring to optimize population reproductive efficiency represents a viable approach for increasing population size. The population of Chinese alligators has a growing age structure, but the high mortality rate of juveniles is ...
Wengang Li, Jingru Liu, Lulu Cui, Ke Sun, Yulin Gao, Qin Wang, Yongkang Zhou, Lan Mei, Pingsi Yi, XiaoBing Wu, ZhenPeng Yu, Tao Pan   +11 more
doaj   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Niche and interspecific relationship of alligator weed (Alternanthera philoxeroides) after a hundred years’ invasion in central China

Heliyon
Alligator weed (Alternanthera philoxeroides (Mart.) Griseb.) is considered one of the worst invasive weeds in China. It was introduced to east China in the late 18th century and gradually spread to central China by the 1930s.
Lanjing Li, Manfred Denich
doaj   +1 more source

Potential Impact of Construction Noise on Selected Zoo Animals

Animals, 2019
In anticipation of a major construction project in an urban New Zealand zoo, a study was initiated to assess the response to construction noise of selected animal species (elephant, giraffe, emu and alligator) previously observed to be sensitive to this ...
Richard Jakob-Hoff, Michael Kingan, Chiaki Fenemore, Gian Schmid, John F. Cockrem, Amanda Crackle, Emily Van Bemmel, Rebecca Connor, Kris Descovich   +8 more
doaj   +1 more source