Results 161 to 170 of about 43,931 (305)

Scaling up malaria intervention "packages" in Senegal: using cost effectiveness data for improving allocative efficiency and programmatic decision-making. [PDF]

Malar J, 2018
Faye S, Cico A, Gueye AB, Baruwa E, Johns B, Ndiop M, Alilio M.   +6 more
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Allocative efficiency of opioid overdose prevention strategies for people incarcerated in New Jersey. [PDF]

Harm Reduct J
Scheidell JD, Frechette JM, Townsend TN, Zhou Q, Manandhar-Sasaki P, Kaldany H, Connelly KL, Cortes AP, Su JI, Charles DL, Braithwaite RS.   +10 more
europepmc   +1 more source

In the interests of time: improving HIV allocative efficiency modelling via optimal time-varying allocations. [PDF]

J Int AIDS Soc, 2016
Shattock AJ, Kerr CC, Stuart RM, Masaki E, Fraser N, Benedikt C, Gorgens M, Wilson DP, Gray RT.   +8 more
europepmc   +1 more source

Public sector efficiency: Leveling the playing field between OECD countries [PDF]

In this paper we seek a robust methodology to measure the relative public spending efficiency of 19 OECD countries over the period 1980-2000. Based on the functional classification of government expenditure, we decompose total public spending into its ...
Adam, Antonis, Delis, Manthos D, Kammas, Pantelis   +2 more
core   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Allocative efficiency analysis of strategies to reduce overdose deaths among people with opioid use disorder and history of incarceration in Connecticut. [PDF]

BMC Public Health
Scheidell JD, Frechette JM, Townsend TN, Zhou Q, Manandhar-Sasaki P, Fiellin DA, Heimer R, Puglisi LB, Charles DL, Su JI, Biegacki ET, Braithwaite RS.   +11 more
europepmc   +1 more source

Which market protocols facilitate fair trading? [PDF]

We study the performance of four market protocols with regard to their ability to equitably distribute the gains from trade among two groups of participants in an exchange economy. We test the protocols by running (computerized) experiments.
Marco LiCalzi, Paolo Pellizzari
core  

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Optimising TB investments in Belarus, Moldova, Kyrgyz Republic, Tajikistan and Uzbekistan: An allocative efficiency analysis. [PDF]

PLOS Glob Public Health
Bowring AL, Martin-Hughes R, Ten Brink D, Burke K, Nidzvetska S, Wulan N, Luong P, Perez-Bennetts E, Scott N.   +8 more
europepmc   +1 more source