Results 161 to 170 of about 66,158 (349)

Activation of TRPA1 and TRPM3 triggers Ca2+ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal horn

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Transient receptor potential ankyrin 1 (TRPA1) and melastatin 3 (TRPM3) activation regulate pre‐ and postsynaptic Ca2+ concentrations and synaptic activity in the dorsal horn of the spinal cord. Left: a model that describes how activation of TRPA1 and TRPM3 channels induces an influx of Ca2+ in the central terminals of sensory ...
Yaroslav E. Andrianov   +10 more
wiley   +1 more source

Antagonism of the Melanocortin System Reduces Cold and Mechanical Allodynia in Mononeuropathic Rats [PDF]

open access: hybrid, 2000
Dorien H. Vrinten   +3 more
openalex   +1 more source

Transcutaneous spinal cord stimulation at alternating intensities preferentially prevents the development of spasticity after contusion SCI in rat

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Previous work in humans and rodents has identified transcutaneous spinal cord stimulation as a promising strategy to reduce spasticity and hyperreflexia after spinal cord injury. The objective of this study was to deliver stimulation protocols with the intensity set (1) above motor threshold, (2) below motor threshold or (3 ...
Dillon C. Malloy   +2 more
wiley   +1 more source

The Role of Peripheral N-Methyl-D-Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review. [PDF]

open access: yesEur J Pain
ABSTRACT Background and Objective NMDA receptors, predominantly located in the central nervous system and known for their roles in synaptic plasticity and central sensitisation of pain and itch, are also expressed in peripheral sensory neurons. Emerging evidence suggests that peripheral NMDA receptors contribute to pathological pain and potentially ...
Tanaka R   +3 more
europepmc   +2 more sources

The effect of environment on post surgical overall well-being and pain sensitivity in an animal model [PDF]

open access: yes, 2016
With chronic post surgical pain affecting up to one third of patients undergoing surgeries and the price of treatment being astoundingly high there has been a transition in research to investigate and identify risk factors. Through identification of risk
Reddy, Archana
core   +1 more source

Local inhibitory effects of dynorphin A-(1–17) on capsaicin-induced thermal allodynia in rhesus monkeys [PDF]

open access: green, 2000
Mei‐Chuan Ko   +4 more
openalex   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

open access: yesGlia, Volume 73, Issue 10, Page 2025-2034, October 2025.
Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc   +10 more
wiley   +1 more source

Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain

open access: yesJournal of Pain Research, 2017
Banulata Gopalsamy, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, Enoch Kumar Perimal Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang ...
Gopalsamy B   +4 more
doaj  

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