Results 171 to 180 of about 66,158 (349)

Weakness, Abdominal and Limb Pain in a 17‐Year‐Old With Type 1 Diabetes

open access: yes
Journal of Paediatrics and Child Health, EarlyView.
Yasmin Abohalima   +5 more
wiley   +1 more source

Development and Validation of a Rapid LC–MS/MS Method for Plasma Analysis of Ketamine, Norketamine, Dehydronorketamine, and Hydroxynorketamine

open access: yesBiomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Ketamine, a well‐established dissociative anesthetic, has recently gained significant attention for its rapid‐acting antidepressant effects, particularly in treatment‐resistant depression. In this study, we developed and validated a state‐of‐the‐art liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the bioanalysis of ...
Jan Thomann   +5 more
wiley   +1 more source

From acute to chronic pain: tapentadol in the progressive stages of this disease entity [PDF]

open access: yes, 2017
OBJECTIVE: Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time. In its chronic phase, pain is not just a symptom but also a disease entity.
Coluzzi, Flaminia   +3 more
core  

Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury

open access: yesNeuron, 2020
Cedric Peirs   +15 more
semanticscholar   +1 more source

Somatosensory Profile of Central Post Stroke Pain of Thalamic Origin: Findings of a Quantitative Sensory Testing Study

open access: yesEuropean Journal of Pain, Volume 29, Issue 8, September 2025.
ABSTRACT Introduction Central post stroke pain (CPSP) is attributed to vascular lesions of the central somatosensory system, including the thalamus. Objective A better characterisation of clinical findings in patients with CPSP after thalamic stroke can facilitate research and treatment of this refractory pain syndrome.
Kristel Berati   +11 more
wiley   +1 more source

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

open access: yesGlia, Volume 73, Issue 9, Page 1817-1840, September 2025.
Main Point Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological ...
Kevin Jayaraj   +5 more
wiley   +1 more source

Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective

open access: yesJOR SPINE, Volume 8, Issue 3, September 2025.
This review of surgically induced IVD puncture injury animal models presents an evolution over decades to include many variations simulating distinct clinical phenotypes of IVDD, and recommends reporting a common set of injury features to facilitate cross‐study comparison.
Charu Jain   +8 more
wiley   +1 more source

The Effect of Electroconvulsive Treatment on Thermal Hyperalgesia and Mechanical Allodynia in a Rat Model of Peripheral Neuropathy

open access: bronze, 1998
Masahiko Shibata   +4 more
openalex   +1 more source

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