Results 201 to 210 of about 66,158 (349)

Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain

open access: yesAdvanced Science, Volume 12, Issue 29, August 7, 2025.
Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang   +9 more
wiley   +1 more source

Pain Coping in Patients With Chronic Migraine and Medication Overuse Headache

open access: yesBrain and Behavior, Volume 15, Issue 8, August 2025.
Pain Coping in patients with Chronic Migraine and Medication Overuse. ABSTRACT Background Chronic migraine (CM) is a leading cause of disability and often linked to medication overuse headache (MOH). Psychological factors, such as pain coping, may contribute to chronification and medication overuse.
Thomas C. van den Hoek   +4 more
wiley   +1 more source

Nerve Injury Induces a Tonic Bilateral μ-Opioid Receptor–mediated Inhibitory Effect on Mechanical Allodynia in Mice [PDF]

open access: bronze, 2004
Heikki Mansikka   +5 more
openalex   +1 more source

Role of NGF and capsaicin-sensitive innervation in TNBS-induced chronic colonic allodynia

open access: bronze, 2000
Laure Delafoy   +3 more
openalex   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

open access: yesMedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li   +8 more
wiley   +1 more source

Sulphonylureas as Adjunct Therapeutic Agents in the Treatment of Autoimmune Conditions: A Narrative Review

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
NLRP3 Inflammasome activation drives inflammatory responses through the production and activation of pro‐inflammatory cytokines. Repurposing sulphonylureas and their derivatives to target NLRP3 may act as adjunct therapeutics for autoimmune conditions. ABSTRACT A rapid and cost‐effective arm of the drug discovery and development process is finding new ...
Jasen Elford   +4 more
wiley   +1 more source

Effects of the Prostaglandin E1 Analog Limaprost on Mechanical Allodynia Caused by Chemotherapeutic Agents in Mice

open access: yesJournal of Pharmacological Sciences, 2009
This study examined in mice whether limaprost, a prostaglandin E1 analog, would relieve allodynia induced by chemotherapeutic agents. Single intraperitoneal injections of paclitaxel, oxaliplatin, and vincristine sulfate induced and gradually increased ...
Punam Gauchan   +4 more
doaj  

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