Results 111 to 120 of about 387 (146)
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The Journal of Immunology, 2022
Pancreatic cancer is one of the most malignant solid tumors with a high mortality rate. Although there have been many trials for effective therapies using chemotherapeutic drugs, such as gemcitabine, pancreatic cancer still shows significantly higher ...
Hyejung Jo +4 more
semanticscholar +2 more sources
Pancreatic cancer is one of the most malignant solid tumors with a high mortality rate. Although there have been many trials for effective therapies using chemotherapeutic drugs, such as gemcitabine, pancreatic cancer still shows significantly higher ...
Hyejung Jo +4 more
semanticscholar +2 more sources
International Immunopharmacology, 2023
Alloferon-1 is an insect polypeptide that has anti-inflammatory, antitumor and antiviral activity. This study aimed to determine the effects of alloferon-1 on estrogen deficiency-induced osteoporosis and explore the associated mechanism using a murine ...
Shuai Qiao +4 more
exaly +4 more sources
Alloferon-1 is an insect polypeptide that has anti-inflammatory, antitumor and antiviral activity. This study aimed to determine the effects of alloferon-1 on estrogen deficiency-induced osteoporosis and explore the associated mechanism using a murine ...
Shuai Qiao +4 more
exaly +4 more sources
Novel analogs of alloferon: Synthesis, conformational studies, pro-apoptotic and antiviral activity
Bioorganic Chemistry, 2016In this study, we report the structure-activity relationships of novel derivatives of the insect peptide alloferon (H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH). The peptide structure was modified by exchanging His at position 9 or 12 for natural or non-natural amino acids.
Mariola Kuczer +2 more
exaly +4 more sources
Molecular Cancer Therapeutics, 2023
Pancreatic cancer frequently metastasizes into one or more organs and tissues located near the pancreas. Metastasis contributes to make curative approach unachievable and bring poor prognosis.
Hyejung Jo +3 more
semanticscholar +2 more sources
Pancreatic cancer frequently metastasizes into one or more organs and tissues located near the pancreas. Metastasis contributes to make curative approach unachievable and bring poor prognosis.
Hyejung Jo +3 more
semanticscholar +2 more sources
Further studies on the antiviral activity of alloferon and its analogues
Journal of Peptide Science, 2011AbstractThe subject of our studies was the synthesis, biological evaluation, and conformational studies of insect tridecapeptide alloferon (H‐His‐Gly‐Val‐Ser‐Gly‐His‐Gly‐Gln‐His‐Gly‐Val‐His‐Gly‐OH) and its analogues such as: [des‐His1]‐, [Lys1]‐, [Arg1]‐, and [Ala1]‐alloferon. These peptides were synthesized to check the influence of the His residue at
Mariola Kuczer
exaly +4 more sources
Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model
International Immunopharmacology, 2012Alloferons are a group of antiviral and anti-tumor peptides primarily isolated from insects and stimulating cytotoxic activity of natural killer cells in mammals including mice and humans. Alloferon-1 is currently used in the treatment of persistent viral infections; however its anti-tumor potential needs further preclinical assessment.
Sergey Chernysh
exaly +4 more sources
Novel biological effects of alloferon and its selected analogues: structure-activity study.
Regulatory Peptides, 2013The subject of this paper is a search for new biological properties of alloferon (H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH) and a series of its analogues. The studies on structure/activity relationship in alloferon, the synthesis of a series of 28 analogues were performed.
M. Kuczer, E. Czarniewska, G. Rosiński
semanticscholar +3 more sources
The long‐term immunological effects of alloferon and its analogues in the mealworm Tenebrio molitor
Insect Science, 2018AbstractThe subject of this article is a search for the long‐term immunological effects of alloferon and 3 structural analogues of alloferon, which were earlier characterized by the highest pro‐apoptotic activity in Tenebrio molitor. The differences in the actions of these peptides on immune response were observed.
E. Czarniewska +3 more
semanticscholar +3 more sources
Activation of NF-κB by alloferon through down-regulation of antioxidant proteins and IκBα
Molecular and Cellular Biochemistry, 2008Alloferon is a 13-amino acid peptide isolated from the bacteria-challenged larvae of the blow fly Calliphora vicina. The pharmaceutical value of the peptide has been well demonstrated by its capacity to stimulate NK cytotoxic activity and interferon (IFN) synthesis in animal and human models, as well as to enhance antiviral and antitumor activities in ...
Cheolju Lee, Sergey Chernysh
exaly +3 more sources
Inflammation
Endometritis is an inflammatory reaction of the uterine lining that can lead to infertility. Alloferon, a linear non-glycosylated oligopeptide, has been recognized for its potent anti-inflammatory and immunomodulatory effects. In light of these attributes, this study aims to explore the potential therapeutic effects of alloferon in alleviating ...
Shitian Chen +9 more
exaly +4 more sources
Endometritis is an inflammatory reaction of the uterine lining that can lead to infertility. Alloferon, a linear non-glycosylated oligopeptide, has been recognized for its potent anti-inflammatory and immunomodulatory effects. In light of these attributes, this study aims to explore the potential therapeutic effects of alloferon in alleviating ...
Shitian Chen +9 more
exaly +4 more sources