Results 131 to 140 of about 387 (146)

Inhibition of Lytic Reactivation of Kaposi'S Sarcoma-Associated Herpesvirus by Alloferon

Antiviral Therapy, 2011
Seyeon Bae, Hang-Rae Kim, Sung-Joon Kim
exaly   +3 more sources

Copper(ii) complexes with alloferon analogues containing phenylalanine H6F and H12F stability and biological activity lower stabilization of complexes compared to analogues containing tryptophan.

Metallomics, 2019
Copper(ii) complex formation processes between alloferon 1 (Allo1) (H1 GVSGH6 GQH9 GVH12G) analogues where the phenylalanine residue is introduced in the place of His residue H6F and H12F have been studied by potentiometric, UV-visible, CD and EPR ...
T. Kowalik-Jankowska, M. Lesiów, K. Krupa, M. Kuczer, E. Czarniewska   +4 more
semanticscholar   +1 more source

The synthesis of immunomodulating peptide alloferon, the active principle of antiviral drug allokine-alpha

Russian Journal of Bioorganic Chemistry, 2006
Two variants of the synthesis of tridecapeptide alloferon, the active principle of antiviral preparation allokine-alpha, were developed on the basis of fragment condensation in solution or on the Merrifield resin. The solid phase variant of the synthesis was shown to be more technological; it allows the preparation of the product at a higher total ...
M. V. Sidorova, A. S. Molokoedov, E. V. Kudryavtseva, M. I. Baldin, D. A. Frid, M. V. Ovchinnikov, Zh. D. Bespalova, V. N. Bushuev   +7 more
openaire   +1 more source

Mono- and polynuclear copper(ii) complexes with fragment of alloferons 1 and 2; combined potentiometric and spectroscopic studies

Dalton Transactions, 2010
Complex formation processes between the SGH(3)GQH(6)GVH(9)G decapeptide fragment of alloferons 1 and 2 and copper(II) ions have been studied by potentiometric, UV-vis, circular dichroism (CD) and electron paramagnetic resonance (EPR) methods. This peptide contains two histidines (H(6) and H(9)) and an N-terminal "albumin-like" Xaa-Yaa-His sequence.
Teresa, Kowalik-Jankowska, Julia, Jezierska, Mariola, Kuczer   +2 more
openaire   +2 more sources

Activation of NF-kappaB by alloferon through down-regulation of antioxidant proteins and IkappaBalpha.

Molecular and cellular biochemistry, 2008
Alloferon is a 13-amino acid peptide isolated from the bacteria-challenged larvae of the blow fly Calliphora vicina. The pharmaceutical value of the peptide has been well demonstrated by its capacity to stimulate NK cytotoxic activity and interferon (IFN) synthesis in animal and human models, as well as to enhance antiviral and antitumor activities in ...
Myung-Jeom, Ryu, Vadim, Anikin, Seok-Ho, Hong, Hyesung, Jeon, Yeon Gyu, Yu, Myeong-Hee, Yu, Sergey, Chernysh, Cheolju, Lee   +7 more
openaire   +1 more source

Effect of alloferon on the cytotoxic activity of NK cells in patients with chronic Epstein-Barr virus infection

Èpidemiologiâ i Infekcionnye Bolezni Aktual'nye voprosy, 2022
Rakityanskaya I.A. Rakityanskaya, R. T. Ryabova, K. A. Kalashnikova   +2 more
semanticscholar   +1 more source

[The synthesis of immunomodulating peptide alloferon, the active component of the antiviral drug allokine-alpha].

Bioorganicheskaia khimiia, 2006
Two variants of the synthesis of tridecapeptide alloferon, the active principle of antiviral preparation allokine-alpha, were developed on the basis of fragment condensation in solution or on the Merrifield resin. The solid phase variant of the synthesis was shown to be more technological; it allows the preparation of the product at a higher total ...
M V, Sidorova, A S, Molokoedov, E V, Kudriavtseva, M I, Baldin, D A, Frid, M V, Ovchinnikov, Zh D, Bespalova, V N, Bushuev   +7 more
openaire   +1 more source

[Serial recombinant expression and activity against tumor cells in vitro of antibacterial peptide Alloferon-1].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2009
To construct a prokaryotic expression system to serially express Alloferon-1 and to determine the anti-tumor activity of its products in vitro.An artificial fusion gene containing 6 x His-EK-8 x Alloferon-1-EK-6 x His sequences was constructed by linking primer PCR.
Qi, Sun, Ai-hua, Sun, Jie, Yan
openaire   +1 more source

[Regulation of proliferation and viability of tumor cells in vitro by alloferon-1 and allostatin-1].

Tsitologiia, 2011
Alloferon-1 (AF) and allostatin-1 (AS) cytotoxic and growth modulating activities have been compared. AF is cationic oligopeptide isolated from the hemolymph of experimentally infected blow fly Calliphora vicina. AS is AF synthetic analog that differs from the parent molecule in two amino acids substituted. It has been shown that both AF and AS have no
V A, Pleskach, I V, Kozhukharova, L L, Alekseenko, N M, Pleskach, V B, Anikin, S I, Chernysh   +5 more
openaire   +1 more source

[Serial recombinant expression and anti-tumor activity in vitro of antibiotic peptide Alloferon-1].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2012
To generate a recombinant expression system of repeated serial antibiotic peptide Alloferon-1 DNA segment with trypsin digestion site and to determine its anti-tumor activity in vitro.A 14 repeated serial DNA segment of Alloferon-1 with a lysine residual at the C-end that acts as the trypsin digestion site was constructed.
Xiao-yin, Xu, Jie, Yan, Qi, Sun
openaire   +1 more source