Results 91 to 100 of about 5,726,852 (304)

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Sinusitis in patients undergoing allogeneic bone marrow transplantation – a review

Brazilian Journal of Otorhinolaryngology
Introduction Sinusitis is a common morbidity in general population, however little is known about its occurrence in severely immunocompromised patients undergoing allogeneic hematopoietic stem cell transplantation.
Joanna Ewa Drozd-Sokolowska, Jacek Sokolowski, Wieslaw Wiktor-Jedrzejczak, Kazimierz Niemczyk   +3 more
doaj   +1 more source

Immune recognition surface construction of Mycobacterium tuberculosis epitope-specific antibody responses in tuberculosis patients identified by peptide microarrays

International Journal of Infectious Diseases, 2017
Background: Understanding of humoral immune responses in tuberculosis (TB) is gaining interest, since B-cells and antibodies may be important in diagnosis as well as protective immune responses.
Davide Valentini, Martin Rao, Giovanni Ferrara, Marc Perkins, Ernest Dodoo, Alimuddin Zumla, Markus Maeurer   +6 more
doaj   +1 more source

Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection [PDF]

, 2009
Background: There is currently no effective AIDS vaccine, emphasizing the importance of developing alternative therapies. Recently, a patient was successfully transplanted with allogeneic, naturally resistant CCR5-negative (CCR5 delta 32) cells, setting ...
Trobridge, Grant D., Chiu Sum Ying, Brian C Beard, Robert A Wu, John J Rossi, Muñoz Nina M., Nina M Muñoz, John J. Rossi, Brian C. Beard, Dorothee von Laer, Laer, Dorothee von, Grant D Trobridge, Beard Brian C., Chiu, Sum Ying, Nina M. Muñoz, Kiem, Hans-Peter, Sum Ying Chiu, Trobridge Grant D., Wu, Robert A., Hans-Peter Kiem, Kiem Hans-Peter, Beard, Brian C., Wu Robert A., von Laer Dorothee, Rossi, John J., Rossi John J., Grant D. Trobridge, Robert A. Wu, Muñoz, Nina M.   +28 more
core   +2 more sources

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

The role of matched sibling donor allogeneic stem cell transplantation in pediatric high-risk acute myeloid leukemia: results from the AML-BFM 98 study

Haematologica, 2012
Background The role of allogeneic stem cell transplantation in post-remission management of children with high-risk acute myeloid leukemia remains controversial.
Jan-Henning Klusmann, Dirk Reinhardt, Martin Zimmermann, Bernhard Kremens, Josef Vormoor, Michael Dworzak, Ursula Creutzig, Thomas Klingebiel   +7 more
doaj   +1 more source

Haematopoietic cell transplantation in Switzerland, changes and results over 20 years: a report from the Swiss Blood Stem Cell Transplantation Working Group for Blood and Marrow Transplantation registry 1997-2016 [PDF]

, 2018
In 1997, the Swiss Blood Stem Cell Transplantation Group (SBST) initiated a mandatory national registry for all haematopoietic stem cell transplants (HCTs) in Switzerland.
Bargetzi, M., Kurt Leibundgut, Passweg, J.R., Renner, Christoph, Chalandon, Yves, Leibundgut, K., Leibundgut, Kurt, Grazia Nicoloso de Faveri, Swiss Blood Stem Cell Transplantation Group, SBST, Thomas Pabst, Christoph Renner, Duchosal, M.A., Baerlocher, Gabriela M, Nair, Gayathri, Ansari, M., Renner, C., Passweg, Jakob R, Sabine Gerull, Hess-Kappas, Ursula, Schanz, U., Schmidt, Adrian, Jakob R. Passweg, Gerull, S., Adrian Schmidt, Pabst, Thomas, Tayfun Güngör, Yves Chalandon, Nair, G., Urs Hess, Antonia Müller, Chalandon, Y., Nicoloso de Faveri, G., Duchosal, Michel A, Müller, Antonia, Masouridi Levrat, Stavroula, Ansari Djaberi, Marc Georges, Masouridi-Levrat, Stavroula, Heim, D., Müller, A., Halter, J.P., Baldomero, H., Masouridi-Levrat, S., Gabriela M. Baerlocher, Bargetzi, Mario, Stussi, Georg, Georg Stussi, Dominik Heim, Jörg P. Halter, Schanz, Urs, Marc Ansari, Michel A. Duchosal, Baerlocher, Gabriela M., Helen Baldomero, Ansari, Marc, Güngör, T., Halter, Jörg P, Nicoloso de Faveri, Grazia, Baerlocher, G.M., Gayathri Nair, Schmidt, A., Pabst, T., Urs Schanz, Stussi, G., Gerull, Sabine, Güngör, Tayfun, Stavroula Masouridi-Levrat, Mario Bargetzi, for the Swiss Blood Stem Cell Transplantation Group (SBST), Baldomero, Helen, Heim, Dominik, Hess, U., Hess, Urs   +71 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Bortezomib treatment followed by a second non-myeloablative allogeneic stem cell transplant in two previously autografted patients with multiple myeloma relapse

Haematologica, 2005
We report two cases of multiple myeloma relapse and progression following a combination of autologous stem cell transplantation and non-myeloablative allogeneic stem cell transplantation.
D Mattei, N Mordini, R Vigna Taglianti, B Bruno, D Rapezzi, A Gallamini   +5 more
doaj  

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source