Results 1 to 10 of about 1,165,162 (267)

Single cell profiling of CD45+ spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injury

Journal of Neuroinflammation, 2022
Background Immune cells play crucial roles after spinal cord injury (SCI). However, incomplete knowledge of immune contributions to injury and repair hinders development of SCI therapies.
Elizabeth S. Fisher, Matthew A. Amarante, Natasha Lowry, Steven Lotz, Farhad Farjood, Sally Temple, Caitlin E. Hill, Thomas R. Kiehl   +7 more
doaj   +1 more source

Wharton’s Jelly-Derived Mesenchymal Stem Cells with High Aurora Kinase A Expression Show Improved Proliferation, Migration, and Therapeutic Potential

Stem Cells International, 2022
Mesenchymal stem cells (MSCs) are effective therapeutic agents that contribute to tissue repair and regeneration by secreting various factors. However, donor-dependent variations in MSC proliferation and therapeutic potentials result in variable ...
Sun Jeong Kim, Sang Eon Park, Jang Bin Jeong, Shin Ji Oh, Alee Choi, Yun Hee Kim, Suk-joo Choi, Soo-young Oh, Gyu Ha Ryu, Hong Bae Jeon, Jong Wook Chang   +10 more
doaj   +1 more source

GMP Compliant Production of a Cryopreserved Adipose-Derived Stromal Cell Product for Feasible and Allogeneic Clinical Use

Stem Cells International, 2022
The emerging field of advanced therapy medicinal products (ATMP) holds promise of treating a variety of diseases. Adipose-derived stromal cells (ASCs) are currently being marketed or tested as cell-based therapies in numerous clinical trials.
Mandana Haack-Sørensen, Ellen Mønsted Johansen, Lisbeth Drozd Højgaard, Jens Kastrup, Annette Ekblond   +4 more
doaj   +1 more source

The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases

Stem Cell Research & Therapy, 2021
The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs.
Chao Yang, Mingjun Wu, Min You, Yu Chen, Maowen Luo, Qiang Chen   +5 more
doaj   +1 more source

Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs

Stem Cell Research & Therapy, 2021
Background There are over 17,000 patients in the US waiting to receive liver transplants, and these numbers are increasing dramatically. Significant effort is being made to obtain functional hepatocytes and liver tissue that can for therapeutic use in ...
M. Ruiz-Estevez, A. T. Crane, P. Rodriguez-Villamil, F. L. Ongaratto, Yun You, A. R. Steevens, C. Hill, T. Goldsmith, D. A. Webster, L. Sherry, S. Lim, N. Denman, W. C. Low, D. F. Carlson, J. R. Dutton, C. J. Steer, O. Gafni   +16 more
doaj   +1 more source

Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation

Scientific Reports, 2020
Interleukin (IL)-6 is a pleiotropic cytokine involved in the regulation of hematological and immune responses. IL-6 is secreted chiefly by stromal cells, but little is known about its precise role in the homeostasis of human mesenchymal stromal cells ...
Akaitz Dorronsoro, Valérie Lang, Izaskun Ferrin, Jon Fernández-Rueda, Lorea Zabaleta, Estibaliz Pérez-Ruiz, Pilar Sepúlveda, César Trigueros   +7 more
doaj   +1 more source

Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

Nature Communications, 2018
The International Stem Cell Initiative tests methods in a multisite study to detect pluripotency and teratoma formation (PluriTest, Embryoid Body and Teratoma methods) in human pluripotent stem cells.
The International Stem Cell Initiative
doaj   +1 more source

Treatment of shoulder osteoarthritis and rotator cuff tears with bone marrow concentrate and whole bone marrow injections

Cogent Medicine, 2019
Background: Human bone marrow has shown promise as a minimally invasive approach in treating a variety of musculoskeletal conditions due to the presence of stem cells, platelets, and growth factors in solution.
Marc Darrow, Brent Shaw, Nicholas Schmidt, Gabrielle Boeger, Saskia Budgett   +4 more
doaj   +1 more source

The Choice of Anticoagulant Influences the Characteristics of Bone Marrow Aspirate Concentrate and Mesenchymal Stem Cell Bioactivity In Vitro

Stem Cells International, 2022
Bone marrow aspirate concentrate (BMC) is commonly used as a therapeutic agent to resolve orthopedic injuries, using its unique cellularity to reduce inflammation and prime the region for repair.
Ryan C. Dregalla, Jessica Ann Herrera, Lucanus Steven Koldewyn, Edward Jeffery Donner   +3 more
doaj   +1 more source

Advances in Recellularization of Decellularized Liver Grafts with Different Liver (Stem) Cells: Towards Clinical Applications

Cells, 2023
Liver transplantation is currently the only curative therapy for patients with acute or chronic liver failure. However, a dramatic gap between the number of available liver grafts and the number of patients on the transplantation waiting list emphasizes ...
Burak Toprakhisar, Catherine M. Verfaillie, Manoj Kumar   +2 more
doaj   +1 more source