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Stem Cells [PDF]

Plastic and Reconstructive Surgery, 2010
Stem cells are self-renewing cells capable of differentiating into multiple cell lines and are classified according to their origin and their ability to differentiate. Enormous potential exists in use of stem cells for regenerative medicine. To produce effective stem cell-based treatments for a range of diseases, an improved understanding of stem cell ...
Björn, Behr, Sae Hee, Ko, Victor W, Wong, Geoffrey C, Gurtner, Michael T, Longaker   +4 more
openaire   +5 more sources

Stem cell-based therapy for human diseases

Signal Transduction and Targeted Therapy, 2022
Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells ...
Duc M. Hoang, P. Pham, Trung Q. Bach, Anh T L Ngo, Q. T. Nguyen, Trang T. K. Phan, G. Nguyen, P. Le, Van T. Hoang, N. Forsyth, M. Heke, L. Nguyen   +11 more
semanticscholar   +1 more source

Cells, Stem Cells, and Cancer Stem Cells [PDF]

Seminars in Reproductive Medicine, 2013
The stem cell field owes a great deal to the previous work conducted by embryologists and researchers devoted to reproductive medicine. The time is coming when this emerging field will pay off in the reproductive sciences by offering new avenues of understanding gametogenesis and early embryonic development.
Aguilar-Gallardo, C, Simon, C
openaire   +4 more sources

Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate.

Cell Stem Cell, 2021
Recent evidence supports the notion that mitochondrial metabolism is necessary for the determination of stem cell fate. Historically, mitochondrial metabolism is linked to the production of ATP and tricarboxylic acid (TCA) cycle metabolites to support ...
R. Chakrabarty, N. Chandel
semanticscholar   +1 more source

Single cell profiling of CD45+ spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injury

Journal of Neuroinflammation, 2022
Background Immune cells play crucial roles after spinal cord injury (SCI). However, incomplete knowledge of immune contributions to injury and repair hinders development of SCI therapies.
Elizabeth S. Fisher, Matthew A. Amarante, Natasha Lowry, Steven Lotz, Farhad Farjood, Sally Temple, Caitlin E. Hill, Thomas R. Kiehl   +7 more
doaj   +1 more source

Wharton’s Jelly-Derived Mesenchymal Stem Cells with High Aurora Kinase A Expression Show Improved Proliferation, Migration, and Therapeutic Potential

Stem Cells International, 2022
Mesenchymal stem cells (MSCs) are effective therapeutic agents that contribute to tissue repair and regeneration by secreting various factors. However, donor-dependent variations in MSC proliferation and therapeutic potentials result in variable ...
Sun Jeong Kim, Sang Eon Park, Jang Bin Jeong, Shin Ji Oh, Alee Choi, Yun Hee Kim, Suk-joo Choi, Soo-young Oh, Gyu Ha Ryu, Hong Bae Jeon, Jong Wook Chang   +10 more
doaj   +1 more source

ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update

Stem Cell Reports, 2021
Summary The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social,
R. Lovell-Badge, Eric Anthony, R. Barker, T. Bubela, A. Brivanlou, M. Carpenter, R. Charo, A. Clark, E. Clayton, Y. Cong, G. Daley, Jianping Fu, M. Fujita, A. Greenfield, S. Goldman, Lori Hill, I. Hyun, R. Isasi, J. Kahn, Kazuto Kato, Jin-Soo Kim, J. Kimmelman, Jurgen Knoblich, Debra J. H. Mathews, N. Montserrat, J. Mosher, M. Munsie, H. Nakauchi, L. Naldini, Gail K. Naughton, Kathy K. Niakan, Ubaka Ogbogu, Roger Pedersen, N. Rivron, H. Rooke, J. Rossant, J. Round, M. Saitou, D. Sipp, J. Steffann, J. Sugarman, Azim M. Surani, J. Takahashi, Fuchou Tang, L. Turner, Patricia J. Zettler, Xiaomei Zhai   +46 more
semanticscholar   +1 more source

GMP Compliant Production of a Cryopreserved Adipose-Derived Stromal Cell Product for Feasible and Allogeneic Clinical Use

Stem Cells International, 2022
The emerging field of advanced therapy medicinal products (ATMP) holds promise of treating a variety of diseases. Adipose-derived stromal cells (ASCs) are currently being marketed or tested as cell-based therapies in numerous clinical trials.
Mandana Haack-Sørensen, Ellen Mønsted Johansen, Lisbeth Drozd Højgaard, Jens Kastrup, Annette Ekblond   +4 more
doaj   +1 more source

The therapeutic applications of mesenchymal stromal cells from human perinatal tissues in autoimmune diseases

Stem Cell Research & Therapy, 2021
The autoimmune diseases are characterized by overactivation of immune cells, chronic inflammation, and immune response to self-antigens, leading to the damage and dysfunction of multiple organs.
Chao Yang, Mingjun Wu, Min You, Yu Chen, Maowen Luo, Qiang Chen   +5 more
doaj   +1 more source

Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs

Stem Cell Research & Therapy, 2021
Background There are over 17,000 patients in the US waiting to receive liver transplants, and these numbers are increasing dramatically. Significant effort is being made to obtain functional hepatocytes and liver tissue that can for therapeutic use in ...
M. Ruiz-Estevez, A. T. Crane, P. Rodriguez-Villamil, F. L. Ongaratto, Yun You, A. R. Steevens, C. Hill, T. Goldsmith, D. A. Webster, L. Sherry, S. Lim, N. Denman, W. C. Low, D. F. Carlson, J. R. Dutton, C. J. Steer, O. Gafni   +16 more
doaj   +1 more source