Results 21 to 30 of about 1,165,162 (267)

Treatment of unresolved lower back pain with platelet-rich plasma injections

Cogent Medicine, 2019
Background: Platelet-Rich Plasma (PRP) is a non-invasive modality that has been used to treat musculoskeletal conditions for the past two decades. Based on our research, there were no publications that studied the effect of PRP on unresloved lower back ...
Marc Darrow, Brent Shaw, Schmidt Nicholas, Xian Li, Gabrielle Boeger   +4 more
doaj   +1 more source

Nitric oxide has contrasting age-dependent effects on the functionality of murine hematopoietic stem cells

Stem Cell Research & Therapy, 2016
Background The success of hematopoietic stem cell (HSC) transplantation is dependent on the quality of the donor HSCs. Some sources of HSCs display reduced engraftment efficiency either because of inadequate number (e.g., fetal liver and cord blood), or ...
Sapana Jalnapurkar, Shweta Singh, Moirangthem Ranjita Devi, Lalita Limaye, Vaijayanti Kale   +4 more
doaj   +1 more source

Do high-volume centers really save more lives? A call for scientific rigor and transparency. Response to Comment on: Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy

Haematologica
Not available.
Wolfgang Bethge, Peter Dreger, German Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy e.V. (DAG-HSZT) - German Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy (DRST)   +2 more
doaj   +1 more source

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

Nature Communications, 2022
By coupling robotic cell culture systems with artificial intelligence–powered image analysis, Schiff et al. identify previously unseen characteristics of Parkinson’s disease in patient skin cells that distinguish them from healthy controls.
Lauren Schiff, Bianca Migliori, Ye Chen, Deidre Carter, Caitlyn Bonilla, Jenna Hall, Minjie Fan, Edmund Tam, Sara Ahadi, Brodie Fischbacher, Anton Geraschenko, Christopher J. Hunter, Subhashini Venugopalan, Sean DesMarteau, Arunachalam Narayanaswamy, Selwyn Jacob, Zan Armstrong, Peter Ferrarotto, Brian Williams, Geoff Buckley-Herd, Jon Hazard, Jordan Goldberg, Marc Coram, Reid Otto, Edward A. Baltz, Laura Andres-Martin, Orion Pritchard, Alyssa Duren-Lubanski, Ameya Daigavane, Kathryn Reggio, NYSCF Global Stem Cell Array® Team, Phillip C. Nelson, Michael Frumkin, Susan L. Solomon, Lauren Bauer, Raeka S. Aiyar, Elizabeth Schwarzbach, Scott A. Noggle, Frederick J. Monsma, Daniel Paull, Marc Berndl, Samuel J. Yang, Bjarki Johannesson   +42 more
doaj   +1 more source

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

Nature Communications, 2019
Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with ...
Edwin A. Rosado-Olivieri, Kendall Anderson, Jennifer H. Kenty, Douglas A. Melton   +3 more
doaj   +1 more source

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

eLife, 2014
Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β
Barak Blum, Adam N Roose, Ornella Barrandon, René Maehr, Anthony C Arvanites, Lance S Davidow, Jeffrey C Davis, Quinn P Peterson, Lee L Rubin, Douglas A Melton   +9 more
doaj   +1 more source

Protocol to assess fatal embolism risks from human stem cells

STAR Protocols, 2023
Summary: Here, we present a protocol to identify the pro-embolic sub-population of human adipose-derived multipotent stromal cells (ADSCs) and predict fatal embolism risks from ADSC infusion.
Fei Ma, Jinlai Zhang, Xin Jin, Pengfei Han, Yuling Liu, Ting Zhang, Kaijing Yan, Y. James Kang   +7 more
doaj   +1 more source

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian, Yannick Braun, Till‐Martin Theilen, Anke Barnbrock, Theresa Rohm, Fabienne Hammant, Nicole Sänger, Aynura Abbasova‐Semiz, Jan‐Henning Klusmann, Thomas Klingebiel, Udo Rolle, Peter Bader, Henning C. Fiegel, Andrea Jarisch   +13 more
wiley   +1 more source

MicroRNAs as Important Regulators Mediate the Multiple Differentiation of Mesenchymal Stromal Cells

Frontiers in Cell and Developmental Biology, 2021
MicroRNAs (miRNAs) are endogenous short non-encoding RNAs which play a critical role on the output of the proteins, and influence multiple biological characteristics of the cells and physiological processes in the body.
Chao Yang, Maowen Luo, Yu Chen, Min You, Qiang Chen, Qiang Chen   +5 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source