Results 41 to 50 of about 15,064,991 (360)
Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body [PDF]
, 2017 Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade.
Annese, Valentina +3 more
core +2 more sources
Identification of the Human Skeletal Stem Cell.
Cell, 2018 Stem cell regulation and hierarchical organization of human skeletal progenitors remain largely unexplored. Here, we report the isolation of a self-renewing and multipotent human skeletal stem cell (hSSC) that generates progenitors of bone, cartilage ...
Charles K. F. Chan +35 more
semanticscholar +1 more source
Protocol to assess fatal embolism risks from human stem cells
STAR Protocols, 2023 Summary: Here, we present a protocol to identify the pro-embolic sub-population of human adipose-derived multipotent stromal cells (ADSCs) and predict fatal embolism risks from ADSC infusion.
Fei Ma +7 more
doaj +1 more source
First steps to define murine amniotic fluid stem cell microenvironment [PDF]
, 2016 Stem cell niche refers to the microenvironment where stem cells reside in living organisms. Several elements define the niche and regulate stem cell characteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix ...
Bertin, Enrica +11 more
core +3 more sources
Clinical applications of stem cell-derived exosomes
Signal Transduction and Targeted TherapyAlthough stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation.
Fei Tan +5 more
semanticscholar +1 more source
Development, 2004 Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow ...
BIANCO, Paolo, P.G. Robey
openaire +4 more sources
Stem Cell Niches: Famished Paneth Cells, Gluttonous Stem Cells [PDF]
Current Biology, 2012 Adult tissue stem cells adjust to environmental changes. A new study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC1 signaling; this in turn stimulates proliferation of neighboring stem cells.
Kim, Tae-Hee, Shivdasani, Ramesh A.
openaire +2 more sources
Nature Communications, 2019 Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with ...
Edwin A. Rosado-Olivieri +3 more
doaj +1 more source
Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway
eLife, 2014 Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β
Barak Blum +9 more
doaj +1 more source
Cells, 2023 Liver transplantation is currently the only curative therapy for patients with acute or chronic liver failure. However, a dramatic gap between the number of available liver grafts and the number of patients on the transplantation waiting list emphasizes ...
Burak Toprakhisar +2 more
doaj +1 more source