Results 31 to 40 of about 1,455,444 (317)

Nitric oxide has contrasting age-dependent effects on the functionality of murine hematopoietic stem cells

Stem Cell Research & Therapy, 2016
Background The success of hematopoietic stem cell (HSC) transplantation is dependent on the quality of the donor HSCs. Some sources of HSCs display reduced engraftment efficiency either because of inadequate number (e.g., fetal liver and cord blood), or ...
Sapana Jalnapurkar, Shweta Singh, Moirangthem Ranjita Devi, Lalita Limaye, Vaijayanti Kale   +4 more
doaj   +1 more source

MicroRNAs as Important Regulators Mediate the Multiple Differentiation of Mesenchymal Stromal Cells

Frontiers in Cell and Developmental Biology, 2021
MicroRNAs (miRNAs) are endogenous short non-encoding RNAs which play a critical role on the output of the proteins, and influence multiple biological characteristics of the cells and physiological processes in the body.
Chao Yang, Maowen Luo, Yu Chen, Min You, Qiang Chen, Qiang Chen   +5 more
doaj   +1 more source

Do high-volume centers really save more lives? A call for scientific rigor and transparency. Response to Comment on: Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy

Haematologica
Not available.
Wolfgang Bethge, Peter Dreger, German Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy e.V. (DAG-HSZT) - German Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy (DRST)   +2 more
doaj   +1 more source

Advances in Recellularization of Decellularized Liver Grafts with Different Liver (Stem) Cells: Towards Clinical Applications

Cells, 2023
Liver transplantation is currently the only curative therapy for patients with acute or chronic liver failure. However, a dramatic gap between the number of available liver grafts and the number of patients on the transplantation waiting list emphasizes ...
Burak Toprakhisar, Catherine M. Verfaillie, Manoj Kumar   +2 more
doaj   +1 more source

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

, 2016
The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency, but their exact functions are poorly understood.
Wu, Zhaoting, Onder, Tamer, Tintara, Supisara, Xia, Qing, Asara, John M., Ratanasirintrawoot, Sutheera, Collins, James J., Ng, Shyh-Chang, Trapnell, Cole, Sliz, Piotr, Chandrasekaran, Sriram, Cacchiarelli, Davide, Wang, Longfei, Mikkelsen, Tarjei, Daley, George Q., Marto, Jarrod A., Teitell, Michael A., Ficarro, Scott B., Ross, Christian A., Shinoda, Gen, Zhang, Jin, Li, Hu, Xie, Wen, Yu, Chunxiao, Loh, Yuin-Han, Cahan, Patrick, Seligson, Marc   +26 more
core   +1 more source

SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells [PDF]

, 2014
Members of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in human cancer, but how they suppress tumorigenesis is currently unclear.
Knoblich, Juergen A., Reichert, Heinrich, Burkard, Thomas R., Homem, Catarina C.F., Saini, Nidhi, Eroglu, Elif, Homem, Catarina C. F., Jiang, Yanrui   +7 more
core   +1 more source

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

Nature Communications, 2019
Pluripotent stem cells can be directed into insulin-producing beta cells in vitro. Here, the authors show that downregulation of YAP, an effector of the Hippo pathway, enhances endocrine progenitor differentiation and the generation of beta-cells with ...
Edwin A. Rosado-Olivieri, Kendall Anderson, Jennifer H. Kenty, Douglas A. Melton   +3 more
doaj   +1 more source

Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting [PDF]

, 2012
INTRODUCTION: Transplantation of neural stem cells (NSCs) is increasingly suggested to become part of future therapeutic approaches to improve functional outcome of various central nervous system disorders. However, recently it has become clear that only
Van Der Linden, Anne-Marie, Van der Linden, Annemie, Herman Goossens, Annemie Van der Linden, Berneman, Zwi Nisan, De Vocht, Nathalie, Debbie Le Blon, Hoornaert, Chloé, Kristien Reekmans, Berneman, Zwi, Jasmijn Daans, Reekmans, Kristien, Nathalie De Vocht, Ponsaerts, Peter, Fransen, Erik, Chloé Hoornaert, Hoornaert, Chlo\ue9, Erik Fransen, Praet, Jelle, Le Blon, Debbie, Zwi Berneman, Goossens, Herman, Peter Ponsaerts, Jelle Praet, Daans, Jasmijn   +24 more
core   +1 more source

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

eLife, 2014
Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes (T2D) lower blood glucose levels but they do not directly alleviate β
Barak Blum, Adam N Roose, Ornella Barrandon, René Maehr, Anthony C Arvanites, Lance S Davidow, Jeffrey C Davis, Quinn P Peterson, Lee L Rubin, Douglas A Melton   +9 more
doaj   +1 more source

PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development

Communications Biology, 2022
The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defects in PU.1 dependent blood lineages, including ...
Xinhui Zhao, Boris Bartholdy, Yukiya Yamamoto, Erica K. Evans, Meritxell Alberich-Jordà, Philipp B. Staber, Touati Benoukraf, Pu Zhang, Junyan Zhang, Bon Q. Trinh, John D. Crispino, Trang Hoang, Mahmoud A. Bassal, Daniel G. Tenen   +13 more
doaj   +1 more source